pH 敏感脂质体递送他利喹达和多柔比星以克服耐药卵巢癌细胞的多药耐药性。
pH sensitive liposomes delivering tariquidar and doxorubicin to overcome multidrug resistance of resistant ovarian cancer cells.
机构信息
School of Life Science and Technology, Xidian University, Xi'an, Shaanxi, 710126, China.
School of Life Science and Technology, Xidian University, Xi'an, Shaanxi, 710126, China.
出版信息
Colloids Surf B Biointerfaces. 2018 Oct 1;170:514-520. doi: 10.1016/j.colsurfb.2018.06.055. Epub 2018 Jun 27.
Multidrug resistance of tumour cells is one of the most important hurdles in tumour chemotherapy. To overcome the multidrug resistance, we constructed a pH-sensitive liposome formulation (pHSL) by loading tariquidar (TQR) and DOX simultaneously in this work. The formulation showed high stability at pH 7.4 and excellent sensitivity at acidic pH, which facilitated the delivery of TQR and DOX into cells. Cellular experiments demonstrated that the pHSL/TQR/DOX 0.05 could almost restore the drug sensitivity of OVCAR8/ADR cells. Therefore, the pH sensitive liposome formulation pHSL/TQR/DOX 0.05 was very promising in treating resistant tumours.
肿瘤细胞的多药耐药性是肿瘤化疗的最重要障碍之一。为了克服多药耐药性，我们在这项工作中构建了一种 pH 敏感脂质体制剂（pHSL），同时装载他奎仑丁（TQR）和 DOX。该制剂在 pH 7.4 时表现出高稳定性，在酸性 pH 时表现出优异的敏感性，这有利于 TQR 和 DOX 递送到细胞内。细胞实验表明，pHSL/TQR/DOX 0.05 几乎可以恢复 OVCAR8/ADR 细胞的药物敏感性。因此，pH 敏感脂质体制剂 pHSL/TQR/DOX 0.05 在治疗耐药肿瘤方面很有前途。
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