新型pH响应性 Gemini 脂质衍生共脂质体用于将阿霉素有效递送至耐药癌细胞
New pH-responsive gemini lipid derived co-liposomes for efficacious doxorubicin delivery to drug resistant cancer cells.
作者信息
Moitra Parikshit, Kumar Krishan, Sarkar Sourav, Kondaiah Paturu, Duan Wei, Bhattacharya Santanu
机构信息
Department of Organic Chemistry, Indian Institute of Science, Bangalore 560012, Karnataka, India.
出版信息
Chem Commun (Camb). 2017 Jul 18;53(58):8184-8187. doi: 10.1039/c7cc03320f.
A gemini version of the amphiphile palmitoyl homocysteine was synthesized. Co-liposomes were prepared using the gemini along with a natural zwitterionic lipid, DOPE and cholesterol at specified ratios. This afforded pH-responsive co-liposomes which could efficiently transport the anticancer drug, doxorubicin (DOX), across the DOX-resistant HeLa cancer cells in response to low pH of cellular endosomes.
合成了两亲性棕榈酰高半胱氨酸的双 Gemini 版本。使用该 Gemini 与天然两性离子脂质二油酰磷脂酰乙醇胺（DOPE）和胆固醇按特定比例制备了共脂质体。这得到了 pH 响应性共脂质体，其能够响应细胞内体的低 pH 值，有效地将抗癌药物阿霉素（DOX）转运穿过耐 DOX 的 HeLa 癌细胞。
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