Asaumi Shintaro, Kawakami Susumu, Sugimoto Sachiko, Matsunami Katsuyoshi, Otsuka Hideaki, Shinzato Takakazu
Graduate School of Biomedical and Health Sciences, Hiroshima University.
Faculty of Pharmacy, Yasuda Women's University.
Chem Pharm Bull (Tokyo). 2018;66(7):757-763. doi: 10.1248/cpb.c18-00281.
Eight alkylated benzoquinone derivatives, named ardisiaquinones A-H, were isolated together with four known compounds from the leaves of Ardisia quinquegona using a combination of different chromatography techniques. Their structures were elucidated by spectroscopy and by the preparation of methyl ethers. Anti-Leishmania activity and cytotoxicity of the isolated compounds were assayed. Some compounds showed moderate anti-Leishmania activity, however, always associated with cytotoxicity.
采用多种色谱技术相结合的方法,从紫金牛的叶子中分离出8种烷基化苯醌衍生物,命名为紫金牛醌A - H,同时还分离出4种已知化合物。通过光谱分析和制备甲基醚对其结构进行了阐明。对分离出的化合物进行了抗利什曼原虫活性和细胞毒性测定。一些化合物表现出中等的抗利什曼原虫活性,然而,总是伴随着细胞毒性。