一种来自大花鸳鸯茉莉的新型杀利什曼原虫皂苷。

A new leishmanicidal saponin from Brunfelsia grandiflora.

作者信息

Fuchino Hiroyuki, Sekita Setsuko, Mori Kanami, Kawahara Nobuo, Satake Motoyoshi, Kiuchi Fumiyuki

机构信息

Research Center for Medicinal Plant Resources, National Institute of Biomedical Innovation, Ibaraki, Japan.

出版信息

Chem Pharm Bull (Tokyo). 2008 Jan;56(1):93-6. doi: 10.1248/cpb.56.93.

DOI:10.1248/cpb.56.93

PMID:18175984

Abstract

A new furostan-type saponin (1) was isolated from the methanolic extract of Brunfelsia grandiflora leaves, together with four known compounds. The chemical structure of 1 was determined by spectroscopic analysis and chemical reaction to be 26-O-beta-D-glucopyranosyl 22alpha-methoxyfurost-3beta,26-diol 3-O-beta-D-xylopyranosyl(1-->3)-{beta-D-glucopyranosyl(1-->2)}-beta-D-glucopyranosyl(1-->4)-beta-D-glucopyranoside. Compound 1 showed potent leishmanicidal activity in vitro against Leishmania major.

摘要

从大花鸳鸯茉莉叶的甲醇提取物中分离出一种新的呋甾烷型皂苷（1），以及四种已知化合物。通过光谱分析和化学反应确定1的化学结构为26 - O - β - D - 吡喃葡萄糖基22α - 甲氧基呋甾 - 3β，26 - 二醇3 - O - β - D - 吡喃木糖基（1→3） - {β - D - 吡喃葡萄糖基（1→2）} - β - D - 吡喃葡萄糖基（1→4） - β - D - 吡喃葡萄糖苷。化合物1在体外对硕大利什曼原虫显示出强大的杀利什曼活性。