儿童对心力衰竭药物的不同反应。
Differential Response to Heart Failure Medications in Children.
作者信息
Miyamoto Shelley D, Sucharov Carmen C, Woulfe Kathleen C
机构信息
Division of Pediatric Cardiology, Department of Pediatrics, University of Colorado Denver School of Medicine and Children's Hospital Colorado, 12700 E 19 Ave, Aurora, CO USA, 80045.
Division of Cardiology, Department of Medicine, University of Colorado Denver School of Medicine, 12700 E 19 Ave, Aurora, CO USA 80045.
出版信息
Prog Pediatr Cardiol. 2018 Jun;49:27-30. doi: 10.1016/j.ppedcard.2018.01.011.
There have been many advances in the treatment of heart failure over the past several years. While these advancements have resulted in improved outcomes in adults with heart failure, these same treatments do not seem to be as efficacious in children with heart failure. Investigations of the failing pediatric heart suggest that there are unique phenotypic, pathologic and molecular differences that could influence how children with heart failure response to adult-based therapies. In this review, several recent studies and the potential implications of their findings on informing the future of the management of pediatric heart failure are discussed.
在过去几年中，心力衰竭的治疗取得了许多进展。虽然这些进展使成年心力衰竭患者的治疗效果得到了改善，但同样的治疗方法对儿童心力衰竭患者似乎并不那么有效。对衰竭小儿心脏的研究表明，存在独特的表型、病理和分子差异，这些差异可能会影响儿童心力衰竭患者对基于成人的治疗的反应。在这篇综述中，讨论了几项近期研究及其结果对指导小儿心力衰竭未来管理的潜在意义。
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