Potential of AT-R-Biased Agonists in Pediatric Heart Failure.
作者信息
Port J David
机构信息
Department of Medicine, Division of Cardiology, and Department of Pharmacology, University of Colorado School of Medicine, Anschutz Medical Campus, Denver, Colorado, USA.
出版信息
JACC Basic Transl Sci. 2020 Nov 23;5(11):1070-1072. doi: 10.1016/j.jacbts.2020.09.008. eCollection 2020 Nov.
Abstract
摘要
相似文献
1
Potential of AT-R-Biased Agonists in Pediatric Heart Failure.
JACC Basic Transl Sci. 2020 Nov 23;5(11):1070-1072. doi: 10.1016/j.jacbts.2020.09.008. eCollection 2020 Nov.
2
β-Arrestin-Biased AT Agonist TRV027 Causes a Neonatal-Specific Sustained Positive Inotropic Effect Without Increasing Heart Rate.
JACC Basic Transl Sci. 2020 Nov 11;5(11):1057-1069. doi: 10.1016/j.jacbts.2020.08.011. eCollection 2020 Nov.
3
Comparative evaluation of biased agonists Sarcosine , d-Alanine -Angiotensin (Ang) II (SD Ang II) and Sarcosine , Isoleucine -Ang II (SI Ang II) and their radioiodinated congeners binding to rat liver membrane AT receptors.
Pharmacol Res Perspect. 2023 Feb;11(1):e01053. doi: 10.1002/prp2.1053.
4
Angiotensin II activates Ca 1.2 Ca channels through β-arrestin2 and casein kinase 2 in mouse immature cardiomyocytes.
J Physiol. 2017 Jul 1;595(13):4207-4225. doi: 10.1113/JP273883. Epub 2017 Apr 20.
5
[A novel way of modification of AT angiotensin receptors to alleviate neonatal and infantile heart failure].
Nihon Yakurigaku Zasshi. 2021;156(6):351-354. doi: 10.1254/fpj.21059.
6
Comparative analyses of downstream signal transduction targets modulated after activation of the AT1 receptor by two β-arrestin-biased agonists.
Front Pharmacol. 2015 Jul 1;6:131. doi: 10.3389/fphar.2015.00131. eCollection 2015.
7
β-Arrestin-Biased Agonist Targeting the Brain ATR (Angiotensin II Type 1 Receptor) Increases Aversion to Saline and Lowers Blood Pressure in Deoxycorticosterone Acetate-Salt Hypertension.
Hypertension. 2021 Feb;77(2):420-431. doi: 10.1161/HYPERTENSIONAHA.120.15793. Epub 2020 Nov 30.
8
Low-dose angiotensin AT receptor β-arrestin-biased ligand, TRV027, protects against cisplatin-induced nephrotoxicity.
Pharmacol Rep. 2020 Dec;72(6):1676-1684. doi: 10.1007/s43440-020-00172-5. Epub 2020 Oct 22.
9
Targeting the Angiotensin II Type 1 Receptor in Cerebrovascular Diseases: Biased Signaling Raises New Hopes.
Int J Mol Sci. 2021 Jun 23;22(13):6738. doi: 10.3390/ijms22136738.
10
Cardioprotective Angiotensin-(1-7) Peptide Acts as a Natural-Biased Ligand at the Angiotensin II Type 1 Receptor.
Hypertension. 2016 Dec;68(6):1365-1374. doi: 10.1161/HYPERTENSIONAHA.116.08118. Epub 2016 Oct 3.
本文引用的文献
1
β-Arrestin-Biased AT Agonist TRV027 Causes a Neonatal-Specific Sustained Positive Inotropic Effect Without Increasing Heart Rate.
JACC Basic Transl Sci. 2020 Nov 11;5(11):1057-1069. doi: 10.1016/j.jacbts.2020.08.011. eCollection 2020 Nov.
2
Update on pediatric heart failure.
Curr Opin Pediatr. 2019 Oct;31(5):598-603. doi: 10.1097/MOP.0000000000000807.
3
Differential Response to Heart Failure Medications in Children.
Prog Pediatr Cardiol. 2018 Jun;49:27-30. doi: 10.1016/j.ppedcard.2018.01.011.
4
Design for the sacubitril/valsartan (LCZ696) compared with enalapril study of pediatric patients with heart failure due to systemic left ventricle systolic dysfunction (PANORAMA-HF study).
Am Heart J. 2017 Nov;193:23-34. doi: 10.1016/j.ahj.2017.07.006. Epub 2017 Jul 17.
5
Pediatric dilated cardiomyopathy hearts display a unique gene expression profile.
JCI Insight. 2017 Jul 20;2(14). doi: 10.1172/jci.insight.94249.
6
Biased ligand of the angiotensin II type 1 receptor in patients with acute heart failure: a randomized, double-blind, placebo-controlled, phase IIB, dose ranging trial (BLAST-AHF).
Eur Heart J. 2017 Aug 7;38(30):2364-2373. doi: 10.1093/eurheartj/ehx196.
7
Angiotensin II activates Ca 1.2 Ca channels through β-arrestin2 and casein kinase 2 in mouse immature cardiomyocytes.
J Physiol. 2017 Jul 1;595(13):4207-4225. doi: 10.1113/JP273883. Epub 2017 Apr 20.
8
Carvedilol for children and adolescents with heart failure: a randomized controlled trial.
JAMA. 2007 Sep 12;298(10):1171-9. doi: 10.1001/jama.298.10.1171.
Zotero 插件