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非裔美国人中大麻素受体1基因（）变异与人格之间显著关联的检测。

Detection of Significant Association Between Variants in Cannabinoid Receptor 1 Gene () and Personality in African-American Population.

作者信息

Yao Yinghao, Xu Yi, Zhao Junsheng, Ma Yunlong, Su Kunkai, Yuan Wenji, Ma Jennie Z, Payne Thomas J, Li Ming D

机构信息

State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Zhejiang University School of Medicine, Hangzhou, China.

Department of Public Health Sciences, University of Virginia, Charlottesville, VA, United States.

出版信息

Front Genet. 2018 Jun 14;9:199. doi: 10.3389/fgene.2018.00199. eCollection 2018.

DOI:10.3389/fgene.2018.00199
PMID:29963071
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6010580/
Abstract

Several studies have revealed significant associations between single nucleotide polymorphisms (SNPs) in the cannabinoid receptor 1 () gene and a broad spectrum of psychiatric disorders such as major depressive disorder (MDD), attention deficit hyperactivity disorder (ADHD), and schizophrenia. Personality traits that are highly related to susceptibility to these conditions have been associated with the variants in subjects of Caucasian origin. However, there are no reported studies regarding the effects of polymorphisms on personality traits in the African-American (AA) population. We performed an imputation-based association analysis for 26 variants with five dimensions of personality in 3,046 AAs. SNPs rs806372 and rs2180619 showed a significant association with extraversion after Bonferroni correction for multiple testing ( < 0.0019). Further, several extraversion-associated SNPs were significantly associated with conscientiousness, agreeableness, and openness. SNP priority score analysis indicated that SNPs rs806368, rs806371, and rs2180619 play a role in the modulation of personality and psychiatric conditions. is important in determining personality traits in the AA population.

摘要

多项研究表明，大麻素受体1（）基因中的单核苷酸多态性（SNP）与多种精神疾病存在显著关联，如重度抑郁症（MDD）、注意力缺陷多动障碍（ADHD）和精神分裂症。与这些疾病易感性高度相关的人格特质与白种人受试者的变异有关。然而，尚无关于多态性对非裔美国人（AA）人群人格特质影响的报道。我们对3046名非裔美国人的26个变异与五维人格进行了基于归因的关联分析。经多重检验的Bonferroni校正后，SNP rs806372和rs2180619与外向性显著相关（<0.0019）。此外，几个与外向性相关的SNP与尽责性、宜人性和开放性显著相关。SNP优先级评分分析表明，SNP rs806368、rs806371和rs2180619在人格和精神疾病的调节中起作用。在确定非裔美国人的人格特质方面很重要。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2717/6010580/fd19403c4fa2/fgene-09-00199-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2717/6010580/b96aecfe1d49/fgene-09-00199-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2717/6010580/e3a28f09e694/fgene-09-00199-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2717/6010580/fd19403c4fa2/fgene-09-00199-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2717/6010580/b96aecfe1d49/fgene-09-00199-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2717/6010580/e3a28f09e694/fgene-09-00199-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2717/6010580/fd19403c4fa2/fgene-09-00199-g003.jpg

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