N Dilek Osman, Ozsay Oguzhan, Karaisli Serkan, Ö Gür Emine, Er Ahmet, G Haciyanli Selda, Kar Haldun, H Dilek Fatma
Department of Surgery, Izmir Katip Çelebi University School of Medicine, Izmir, Turkey.
Department of Pathology, Izmir Katip Çelebi University, Ataturk Research and Education Hospital, Izmir, Turkey.
Euroasian J Hepatogastroenterol. 2018 Jan-Jun;8(1):1-5. doi: 10.5005/jp-journals-10018-1249. Epub 2018 May 1.
The term multiple primary tumor (MPT) is used to describe cases where two or more primary tumors show no histopathological similarities in between. Multiple primary tumor cases have begun to increase in recent years as a result of the increase in life expectancy because of the increase in life standards and progress in diagnostic methods. In this study, MPT cases with periampullary tumors that underwent Whipple procedure were discussed in the light of literature data.
The patient files of 223 cases with periampullary tumors that underwent Whipple procedure in our hospital during the last 6 years were examined retrospectively. More than one primary tumor was detected in 21 patients.
Periampullary carcinomas were detected as a second primary tumor in 18 patients. First primary tumor was periampullary carcinoma in 3 patients that underwent Whipple procedure. After the Whipple procedure, 5 patients died due to early complications in the first 30 days and 6 patients died due to metastases and additional problems that developed during follow-up.
The incidence of MPT has been reported as 0.7 to 14.5% in the literature. Most of them are multiple primary case presentations. In patient management, it is recommended that each tumor should be evaluated independently of its own characteristics, and treatment and follow-up should be planned accordingly.
The MPT cases are increasing. The possibility of MPT as well as metastasis should be kept in mind during the evaluation of tumor foci seen during diagnosis and follow-up of patients. The characteristics of each tumor, survival, and prognosis should be evaluated separately and the most appropriate treatment should be offered to the patient. It is recommended that synchronic primary tumors which are considered to be surgically resectable without metastasis should be removed in the same session. Dilek ON, Ozsay O, Karaisli S, Gür EÖ, Er A, Haciyanli SG, Kar H, Dilek FH. Striking Multiple Primary Tumors that underwent Whipple Procedure due to Periampullary Carcinoma: An Analysis of 21 Cases. Euroasian J Hepato-Gastroenterol 2018;8(1):1-5.
术语“多原发性肿瘤（MPT）”用于描述两个或更多原发性肿瘤之间不存在组织病理学相似性的病例。由于生活水平提高和诊断方法进步导致预期寿命增加，近年来多原发性肿瘤病例开始增多。在本研究中，根据文献数据对接受胰十二指肠切除术的壶腹周围肿瘤的MPT病例进行了讨论。
回顾性检查我院过去6年中223例接受胰十二指肠切除术的壶腹周围肿瘤患者的病历。21例患者检测到不止一个原发性肿瘤。
18例患者的第二原发性肿瘤为壶腹周围癌。3例接受胰十二指肠切除术的患者第一原发性肿瘤为壶腹周围癌。胰十二指肠切除术后，5例患者在术后30天内死于早期并发症，6例患者死于随访期间出现的转移和其他问题。
文献报道MPT的发生率为0.7%至14.5%。其中大多数是多原发性病例表现。在患者管理中，建议应根据每个肿瘤自身的特征独立评估，并相应地规划治疗和随访。
MPT病例正在增加。在评估患者诊断和随访期间发现的肿瘤病灶时，应牢记MPT以及转移的可能性。应分别评估每个肿瘤的特征、生存率和预后，并为患者提供最合适的治疗。建议在同一次手术中切除被认为可手术切除且无转移的同步原发性肿瘤。迪莱克·奥恩（Dilek ON）、厄兹赛伊（Ozsay O）、卡拉伊斯利（Karaisli S）、居尔·厄兹奥卢（Gür EÖ）、埃尔·A（Er A）、哈齐亚尼利·SG（Haciyanli SG）、卡尔·H（Kar H）、迪莱克·FH（Dilek FH）。因壶腹周围癌接受胰十二指肠切除术的显著多原发性肿瘤：21例分析。《欧亚肝脏胃肠病学杂志》2018年；8（1）：1 - 5。
