Komatsu Hiroko, Yagasaki Kaori, Hamamoto Yasuo, Takebayashi Toru
Faculty of Nursing and Medical Care, Keio University, Tokyo, Japan.
Keio Cancer Center, Keio University School of Medicine, Tokyo, Japan.
Asia Pac J Oncol Nurs. 2018 Jul-Sep;5(3):307-313. doi: 10.4103/apjon.apjon_8_18.
This study aims to ascertain the incidence and association of falls and physical inactivity in patients with gastrointestinal cancer and hand-foot syndrome (HFS) after receiving chemotherapy or targeted therapy.
The present cross-sectional study was conducted on 50 outpatients with HFS of Grade 1 or above, according to the National Cancer Institute Common Terminology Criteria for Adverse Events, following the receipt of chemotherapy or targeted therapy for gastrointestinal cancer in Japan between November 2016 and February 2017. For measurement, Dermatology Life Quality Index (DLQI) and the International Physical Activity Questionnaire were used. Data were analyzed by logistic regression analysis.
Of the participants, 18% experienced falls and 60% reported physical inactivity. Multivariate logistic regression revealed that the DLQI treatment domain score was the only factor associated with falls (odds ratio [OR] =8.01, 95% confidence interval [CI] =1.27-50.63, = 0.027). Physical inactivity was associated with DLQI symptom and feeling domain scores (OR = 5.54, 95% CI = 1.26-24.33, = 0.023) and the with-oxaliplatin or paclitaxel regimen (OR = 3.71, 95% CI = 1.06-13.03, = 0.041).
The results of the present study suggest patients should be informed that HFS is a risk factor for physical inactivity and falls.
本研究旨在确定胃肠道癌患者在接受化疗或靶向治疗后发生跌倒及身体活动不足的发生率和相关性，以及手足综合征（HFS）与之的关系。
本横断面研究针对2016年11月至2017年2月期间在日本接受胃肠道癌化疗或靶向治疗后出现1级及以上HFS的50名门诊患者进行。测量采用皮肤病生活质量指数（DLQI）和国际体力活动问卷。数据通过逻辑回归分析进行分析。
参与者中，18%经历过跌倒，60%报告有身体活动不足。多因素逻辑回归显示，DLQI治疗领域得分是与跌倒相关的唯一因素（比值比[OR]=8.01，95%置信区间[CI]=1.27 - 50.63，P = 0.027）。身体活动不足与DLQI症状和感受领域得分相关（OR = 5.54，95% CI = 1.26 - 24.33，P = 0.023），也与含奥沙利铂或紫杉醇的治疗方案相关（OR = 3.71，95% CI = 1.06 - 13.03，P = 0.041）。
本研究结果表明，应告知患者HFS是身体活动不足和跌倒的危险因素。
