衰老与阿尔茨海默病：从分子到系统水平的比较和关联。
Aging and Alzheimer's disease: Comparison and associations from molecular to system level.
机构信息
CAS Key Laboratory of Computational Biology, CAS-MPG Partner Institute for Computational Biology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Nutrition and Health, Shanghai Institutes for Biological Sciences, University of Chinese Academy of Sciences, Chinese Academy of Sciences , Shanghai, China.
出版信息
Aging Cell. 2018 Oct;17(5):e12802. doi: 10.1111/acel.12802. Epub 2018 Jul 2.
Abstract
Alzheimer's disease is the most prevalent cause of dementia, which is defined by the combined presence of amyloid and tau, but researchers are gradually moving away from the simple assumption of linear causality proposed by the original amyloid hypothesis. Aging is the main risk factor for Alzheimer's disease that cannot be explained by amyloid hypothesis. To evaluate how aging and Alzheimer's disease are intrinsically interwoven with each other, we review and summarize evidence from molecular, cellular, and system level. In particular, we focus on study designs, treatments, or interventions in Alzheimer's disease that could also be insightful in aging and vice versa.
摘要
阿尔茨海默病是痴呆症最常见的病因，痴呆症的定义是淀粉样蛋白和 tau 蛋白的共同存在，但研究人员正在逐渐摒弃最初淀粉样蛋白假说所提出的简单线性因果关系假设。衰老（aging）是阿尔茨海默病的主要风险因素，这不能用淀粉样蛋白假说解释。为了评估衰老和阿尔茨海默病是如何内在交织在一起的，我们从分子、细胞和系统水平上回顾和总结了证据。特别是，我们专注于阿尔茨海默病的研究设计、治疗或干预措施，这些措施反过来也可能对衰老有启发。
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