Montagnier L
Ann Intern Med. 1985 Nov;103(5):689-93. doi: 10.7326/0003-4819-103-5-689.
Recent data indicate that the lymphadenopathy-associated virus (LAV) is morphologically similar to animal lentiviruses, such as equine infectious anemia and visna viruses. This finding, together with the cross-reactivity of the core proteins of LAV with those of the equine infectious anemia virus and a similarity in genome structure and biological properties, allows LAV to be placed in the retroviral subfamily of Lentivirinae. Molecular data indicate a high degree of genetic variation of the virus, especially in the envelope gene, which have important implications for the origin of the virus (the T4 lymphotropism may be a recently acquired property) and for future immunization. Another problem is the role of viral infection in the induction of irreversible immunodeficiency. This syndrome occurs in a minority of infected persons, who generally have in common a past of antigenic stimulation and of immune depression before LAV infection.
最近的数据表明，淋巴结病相关病毒（LAV）在形态上与动物慢病毒相似，如马传染性贫血病毒和维斯纳病毒。这一发现，连同LAV核心蛋白与马传染性贫血病毒核心蛋白的交叉反应性以及基因组结构和生物学特性的相似性，使得LAV可被归入慢病毒亚科的逆转录病毒家族。分子数据表明该病毒具有高度的遗传变异性，尤其是在包膜基因方面，这对病毒的起源（嗜T4淋巴细胞特性可能是最近获得的特性）以及未来的免疫接种具有重要意义。另一个问题是病毒感染在诱导不可逆免疫缺陷中的作用。这种综合征发生在少数感染者中，这些感染者通常在感染LAV之前有过抗原刺激和免疫抑制的经历。
