Department of Cell Biology & Institute of Biomedicine, National Engineering Research Center of Genetic Medicine, Guangdong Provincial Key Laboratory of Bioengineering Medicine, College of Life Science and Technology, Jinan University, Guangzhou, Guangdong 510632, China; Tea Research Institute, Guangdong Academy of Agricultural Sciences/ Guangdong Provincial Key Laboratory of Tea Plant Resources Innovation & Utilization, Dafeng Road 6, Tianhe District, Guangzhou 510640, China.
Tea Research Institute, Guangdong Academy of Agricultural Sciences/ Guangdong Provincial Key Laboratory of Tea Plant Resources Innovation & Utilization, Dafeng Road 6, Tianhe District, Guangzhou 510640, China.
Biochem Biophys Res Commun. 2018 Sep 5;503(2):408-413. doi: 10.1016/j.bbrc.2018.06.157. Epub 2018 Jul 6.
Human ABCG2 is one of the most important ATP-binding cassette (ABC) transporters. This protein functions as a xenobiotic transporter of large, hydrophobic, positively or negatively charged molecules, a wide variety anticancer drugs, fluorescent dyes, and different toxic compounds found in normal food. SNPs in ABCG2 may affect absorption and distribution of these substrates, altering the accumulation, effectiveness and toxicity of compounds or drugs in large populations. Its transport properties have been implicated clinically and ABCG2 expression is linked with different disease states. We reviewed the SNPs of ABCG2 in clinical relevance about gout, acute myeloid leukemia, solid tumors, and other diseases.
人 ABCG2 是最重要的三磷酸腺苷结合盒（ABC）转运蛋白之一。这种蛋白质作为一种外来生物转运体，可转运大型、疏水性、带正电荷或负电荷的分子，包括各种抗癌药物、荧光染料和正常食物中的不同有毒化合物。ABCG2 中的单核苷酸多态性（SNP）可能会影响这些底物的吸收和分布，改变化合物或药物在大人群中的积累、有效性和毒性。其转运特性在临床上有相关的应用，ABCG2 的表达与不同的疾病状态有关。我们回顾了 ABCG2 的 SNPs 在痛风、急性髓性白血病、实体瘤和其他疾病中的临床相关性。
