体内淘选技术的现状：为药物靶向的未来设计特异性和亲和力。
Current state of in vivo panning technologies: Designing specificity and affinity into the future of drug targeting.
机构信息
Department of Bioengineering, University of Washington, Seattle, WA 98195, United States; Molecular Engineering and Sciences Institute, University of Washington, Seattle, WA 98195, United States.
Department of Bioengineering, University of Washington, Seattle, WA 98195, United States; Molecular Engineering and Sciences Institute, University of Washington, Seattle, WA 98195, United States; Institute for Protein Design, University of Washington, Seattle, WA 98195, United States.
出版信息
Adv Drug Deliv Rev. 2018 May;130:39-49. doi: 10.1016/j.addr.2018.06.015. Epub 2018 Jun 28.
Abstract
Targeting ligands are used in drug delivery to improve drug distribution to desired cells or tissues and to facilitate cellular entry. In vivo biopanning, whereby billions of potential ligand sequences are screened in biologically-relevant and complex conditions, is a powerful method for identification of novel target ligands. This tool has impacted drug delivery technologies and expanded our arsenal of therapeutics and diagnostics. Within this review we will discuss current in vivo panning technologies and ways that these technologies can be improved to advance next-generation drug delivery strategies.
摘要
靶向配体被用于药物输送中，以改善药物向所需细胞或组织的分布，并促进细胞进入。体内生物淘选，即在生物学相关和复杂的条件下筛选数十亿个潜在的配体序列，是鉴定新型靶标配体的有力方法。该工具已影响药物输送技术，并扩展了我们的治疗和诊断武器库。在本篇综述中，我们将讨论当前的体内淘选技术以及如何改进这些技术以推进下一代药物输送策略。
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