Ewing E P, Chandler F W, Spira T J, Brynes R K, Chan W C
Arch Pathol Lab Med. 1985 Nov;109(11):977-81.
Lymph nodes of patients symptomatically infected with the acquired immunodeficiency syndrome (AIDS) virus show a spectrum of morphologic changes ranging from marked lymphoid hyperplasia to marked lymphocytic depletion. These changes can be grouped into three distinct patterns. The type I pattern features follicular and paracortical hyperplasia, and is associated with chronic lymphadenopathy. The type II pattern, which shows diffuse lymphoid hyperplasia but loss of germinal centers, signifies evolution of chronic lymphadenopathy to AIDS. The type III pattern shows marked lymphocytic depletion and represents the end-stage lymph node seen in fatal AIDS. These histologic patterns are closely correlated with the clinical and immunologic status of patients infected with the AIDS virus.
有获得性免疫缺陷综合征（艾滋病）病毒症状性感染的患者的淋巴结呈现出一系列形态学变化，范围从明显的淋巴样增生到明显的淋巴细胞耗竭。这些变化可分为三种不同模式。I型模式的特征是滤泡和副皮质增生，与慢性淋巴结病相关。II型模式表现为弥漫性淋巴样增生但生发中心缺失，标志着慢性淋巴结病向艾滋病的演变。III型模式表现为明显的淋巴细胞耗竭，代表致命性艾滋病中所见的终末期淋巴结。这些组织学模式与感染艾滋病病毒患者的临床和免疫状态密切相关。
