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[与艾滋病相关的颈部淋巴结病。组织学特征的病程。诊断和预后价值]

[Cervical adenopathies in relation to AIDS. Course of histological aspects. Diagnostic and prognostic value].

作者信息

Marche C, Diebold J, Gehanno P, Bouton C, Neguesse Y

出版信息

Ann Otolaryngol Chir Cervicofac. 1985;102(5):299-303.

PMID:4037614
Abstract

Histopathologic appearances of lymph nodes during acquired immune deficiency syndrome (AIDS) and related conditions are analyzed, with emphasis on the diagnostic and prognostic value of cervical gland biopsy at the lymphadenopathic stage. Details are given of the characteristics of the follicular hyperplasia of the lymph nodes (type I), which appears to be the initial lesion and is possibly regressive, and emphasis placed on the poor prognostic significance of the hyperplasia simulating a Castleman syndrome and of the forms simulating an angioimmunoblastic lymphadenopathy (type II). Findings suggest that the appearance, in a still hyperplastic lymph nodes, of foci of pseudo-angioimmunoblastic homogenization, of fibroedema with lymphoid depletion or conjunctival vascular proliferation may be the initial sign of a course towards the glandular atrophy (type III) or Kaposi's sarcoma which are the attribute of confirmed AIDS.

摘要

分析了获得性免疫缺陷综合征(AIDS)及相关病症期间淋巴结的组织病理学表现,重点关注淋巴结病阶段宫颈腺活检的诊断和预后价值。详细介绍了淋巴结滤泡增生(I型)的特征,其似乎是初始病变且可能会消退,并强调了模拟卡斯尔曼综合征的增生以及模拟血管免疫母细胞性淋巴结病的形式(II型)的不良预后意义。研究结果表明,在仍处于增生状态的淋巴结中出现假血管免疫母细胞性均质化灶、伴有淋巴细胞耗竭的纤维水肿或结膜血管增生,可能是朝着腺体萎缩(III型)或卡波西肉瘤发展的初始迹象,而腺体萎缩或卡波西肉瘤是确诊AIDS的特征。

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