[Changes in skeletal muscles in experimental thyrotoxic myopathy].

In an experimental model of thyrotoxic myopathy in mice certain decrease in average diameter of muscle fibers (MF) has been revealed (by 16%). In 1-20% of the MF various types of focal pathologic reactions (loss of cross and longitudinal striation, glial, glomerular and adipose degeneration, Zenker's necrosis) increasing number, structural changes and position of nuclei are observed. Degree of atrophy and part of the altered fibers depend on duration and severity of thyrotoxicosis. Morphologic disorders localize focally and are not so vast as to be the cause of muscle weakness. The main cause of the latter and of the structural disorders in the skeletal muscle at thyrotoxic myopathy is, evidently, slacken of the hormonal control in cyclic adenosine monophosphate-dependent processes.