Department of Ophthalmology, Duke University, Durham, NC.
J Glaucoma. 2018 Jul;27 Suppl 1:S29-S31. doi: 10.1097/IJG.0000000000000917.
Exfoliation glaucoma (XFG) is the most common identifiable cause of open-angle glaucoma worldwide, and results from the accumulation of extracellular fibrillary material (XFM) within the trabecular meshwork and the Schlemm canal leading to increased intraocular pressure and potential blindness. Immunohistochemical and mass spectrometry analyses have revealed that XFM is a highly glycosylated proteinaceous complex that is extremely resistant to degradation both within the body and under experimental conditions. The protein core contains a wide variety of proteins, including basement membrane proteins, elastic fiber proteins, latent TGFβ proteins, metalloproteinases, chaperone proteins, complement proteins, lysyl oxidase-like 1 (LOXL1), and apolipoprotein E (ApoE). This supplemental section identifies the advances in knowledge and current understanding of the components within XFM with a specific focus on the most recent work defining proteins within XFM and to pose several biological questions that remain unanswered.
剥脱性青光眼（XFG）是全球最常见的可识别的开角型青光眼病因，其发病机制是小梁网和施莱姆管内细胞外纤维状物质（XFM）的蓄积，导致眼内压升高和潜在的失明。免疫组化和质谱分析表明，XFM 是一种高度糖基化的蛋白复合物，在体内和实验条件下都极难降解。其蛋白核心包含多种蛋白，包括基底膜蛋白、弹性纤维蛋白、潜伏 TGFβ 蛋白、金属蛋白酶、伴侣蛋白、补体蛋白、赖氨酰氧化酶样 1（LOXL1）和载脂蛋白 E（ApoE）。这部分补充内容明确了 XFM 内成分的知识进展和当前认识，特别关注最近对 XFM 内蛋白的定义工作，并提出了几个尚未解答的生物学问题。
