Panasenko O M, Borin M L, Azizova O A, Arnol'd K
Biofizika. 1985 Sep-Oct;30(5):822-7.
Surface potential of human plasma lipoproteins was studied by the use of positively charged spin probe. The calculated values of surface potential of high and low density lipoproteins appeared to be -29 +/- 1 and -16 +/- 1 respectively. It was shown that lipid peroxidation process induces an increase of surface potential of both high and low density lipoproteins. Probably, it is connected with the increase of the negative charge density on their surface. This fact can play an important role in pathogenesis of diseases with lipid metabolism and lipid peroxidation level disorders in plasma (atherosclerosis, ischemic heart disease etc.).
利用带正电荷的自旋探针研究了人血浆脂蛋白的表面电位。高密度脂蛋白和低密度脂蛋白表面电位的计算值分别为-29±1和-16±1。结果表明，脂质过氧化过程会导致高密度脂蛋白和低密度脂蛋白的表面电位升高。这可能与它们表面负电荷密度的增加有关。这一事实可能在血浆脂质代谢和脂质过氧化水平紊乱相关疾病（动脉粥样硬化、缺血性心脏病等）的发病机制中起重要作用。
