Department of Biological Science and Technology, National Chiao Tung University, 75 Boai Street, Hsinchu 300, Taiwan.
Division of Chest Medicine, Department of Internal Medicine, Hsinchu Mackay Memorial Hospital, 690 Section 2, Guangfu Road, Hsinchu 300, Taiwan.
Int J Environ Res Public Health. 2018 Jul 1;15(7):1380. doi: 10.3390/ijerph15071380.
Air pollution is a very critical issue worldwide, particularly in developing countries. Particulate matter (PM) is a type of air pollution that comprises a heterogeneous mixture of different particle sizes and chemical compositions. There are various sources of fine PM (PM), and the components may also have different effects on people. The pathogenesis of PM in several diseases remains to be clarified. There is a long history of epidemiological research on PM in several diseases. Numerous studies show that PM can induce a variety of chronic diseases, such as respiratory system damage, cardiovascular dysfunction, and diabetes mellitus. However, the epidemiological evidence associated with potential mechanisms in the progression of diseases need to be proved precisely through in vitro and in vivo investigations. Suggested mechanisms of PM that lead to adverse effects and chronic diseases include increasing oxidative stress, inflammatory responses, and genotoxicity. The aim of this review is to provide a brief overview of in vitro and in vivo experimental studies of PM in the progression of various diseases from the last decade. The summarized research results could provide clear information about the mechanisms and progression of PM-induced disease.
空气污染是一个全球性的严重问题，尤其是在发展中国家。颗粒物（PM）是一种空气污染，由不同粒径和化学成分的异质混合物组成。细颗粒物（PM）有多种来源，其成分也可能对人体产生不同的影响。PM 在几种疾病中的发病机制仍有待阐明。PM 在几种疾病中的流行病学研究历史悠久。大量研究表明，PM 可诱发多种慢性疾病，如呼吸系统损伤、心血管功能障碍和糖尿病。然而，与疾病进展相关的潜在机制的流行病学证据需要通过体外和体内研究来精确证实。导致不良影响和慢性疾病的 PM 建议机制包括增加氧化应激、炎症反应和遗传毒性。本文综述的目的是从过去十年中提供 PM 在各种疾病进展中的体外和体内实验研究的简要概述。总结的研究结果可以提供关于 PM 诱导疾病的机制和进展的明确信息。
