Mun Hye Young, Prismasari Septika, Hong Jeong Hee, Lee Hana, Kim Doyong, Kim Han Sung, Shin Dong Min, Kang Jung Yun
Department of Dental Hygiene, College of Software and Digital Healthcare Convergence, Yonsei University, Wonju 26493, Korea.
Department of Physiology, College of Medicine, Gachon University, Lee Gil Ya Cancer and Diabetes Institute, Incheon 21999, Korea.
Korean J Physiol Pharmacol. 2025 Jan 1;29(1):9-19. doi: 10.4196/kjpp.24.115. Epub 2024 Oct 31.
Fine particulate matter (FPM) is a major component of air pollution and has emerged as a significant global health concern owing to its adverse health effects. Previous studies have investigated the correlation between bone health and FPM through cohort or review studies. However, the effects of FPM exposure on bone health are poorly understood. This study aimed to investigate the effects of FPM on bone health and elucidate these effects and using mice. Micro-CT analysis revealed FPM exposure decreased bone mineral density, trabecular bone volume/total volume ratio, and trabecular number in the femurs of mice, while increasing trabecular separation. Histological analysis showed that the FPM-treated group had a reduced trabecular area and an increased number of osteoclasts in the bone tissue. Moreover, studies revealed that low concentrations of FPM significantly enhanced osteoclast differentiation. These findings further support the notion that short-term FPM exposure negatively impacts bone health, providing a foundation for further research on this topic.
细颗粒物（FPM）是空气污染的主要成分，由于其对健康的不利影响，已成为全球重大的健康问题。以往的研究通过队列研究或综述研究调查了骨骼健康与FPM之间的相关性。然而，FPM暴露对骨骼健康的影响尚不清楚。本研究旨在通过使用小鼠来研究FPM对骨骼健康的影响并阐明这些影响。显微CT分析显示，FPM暴露降低了小鼠股骨的骨矿物质密度、骨小梁体积/总体积比和骨小梁数量，同时增加了骨小梁间距。组织学分析表明，FPM处理组的骨小梁面积减少，骨组织中的破骨细胞数量增加。此外，研究表明低浓度的FPM显著增强破骨细胞分化。这些发现进一步支持了短期FPM暴露对骨骼健康有负面影响的观点，为该主题的进一步研究奠定了基础。
