a Division of Haematology/Oncology , The Hospital for Sick Children , Toronto , Canada.
b Department of Hematology/Oncology , Blood and Marrow Transplant Program, Cancer and Blood Disorders Institute, Johns Hopkins All Children's Hospital , St. Petersburg , FL , USA.
Leuk Lymphoma. 2019 Feb;60(2):385-394. doi: 10.1080/10428194.2018.1474522. Epub 2018 Jul 3.
The purpose was to describe the incidence and risk factors of congestive heart failure (CHF) among children with acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML). We included 2053 children (≤18 years) with first primary ALL and AML diagnosed 1992-2010 and registered in the Pediatric Oncology Group of Ontario Networked Information System. We identified CHF events through linked administrative databases. At 10 years, the cumulative incidence of CHF was 1.7% in ALL and 7.5% in AML. Factors associated with CHF in ALL were female gender, age <1 year at cancer diagnosis, irradiation and cumulative anthracycline dose ≥250 mg/m. Irradiation was the only risk factor in AML patients. Of the 23 patients with CHF during active therapy, one developed CHF following treatment completion. Incidence of CHF were 1.7% in ALL and 7.5% in AML. Most with CHF during active therapy did not develop CHF after treatment completion.
目的在于描述急性淋巴细胞白血病（ALL）和急性髓细胞白血病（AML）患儿充血性心力衰竭（CHF）的发生率和危险因素。我们纳入了 2053 名于 1992 年至 2010 年间首次确诊为 ALL 和 AML 的≤18 岁儿童，并登记在安大略儿科肿瘤组网络信息系统中。我们通过关联的行政数据库确定了 CHF 事件。10 年后，ALL 患儿中 CHF 的累积发生率为 1.7%，AML 患儿为 7.5%。ALL 患儿中与 CHF 相关的因素包括女性、癌症诊断时年龄<1 岁、放疗和累积蒽环类药物剂量≥250mg/m。放疗是 AML 患儿唯一的危险因素。在 23 名接受积极治疗的 CHF 患儿中，有 1 名在治疗完成后发生 CHF。ALL 和 AML 患儿的 CHF 发生率分别为 1.7%和 7.5%。大多数在治疗期间发生 CHF 的患儿在治疗完成后并未发生 CHF。
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