硝普钠和8-溴环磷酸鸟苷对大鼠尾动脉电活动和机械活动的影响。
The effects of sodium nitroprusside and 8-bromo-cyclic GMP on electrical and mechanical activities of the rat tail artery.
作者信息
Cheung D W, MacKay M J
出版信息
Br J Pharmacol. 1985 Sep;86(1):117-24. doi: 10.1111/j.1476-5381.1985.tb09441.x.
Abstract
The effects of sodium nitroprusside and 8-bromo-guanosine 3':5'-cyclic monophosphate (8-bromocyclic GMP) on the electrical and mechanical activities of the rat tail artery were compared. The inhibitory effects of sodium nitroprusside on the contractions induced by noradrenaline, phenylephrine, KC1 and clonidine were mimicked by 8-bromo-cyclic GMP. Sodium nitroprusside and 8-bromo-cyclic GMP increased the resting membrane potential only in preparations with low initial resting membrane potentials. In tissues previously contracted and depolarized with noradrenaline, KC1 and clonidine, both sodium nitroprusside and 8-bromo-cyclic GMP caused relaxation without significantly affecting the membrane potential. Both sodium nitroprusside and 8-bromo-cyclic GMP abolished neurally-mediated contractions without any significant effect on the electrical responses. These results suggest that the actions of sodium nitroprusside and 8-bromo-cyclic GMP are not related to membrane hyperpolarization or inhibition of membrane excitability.
摘要
比较了硝普钠和8-溴鸟苷3':5'-环一磷酸（8-溴环磷酸鸟苷）对大鼠尾动脉电活动和机械活动的影响。8-溴环磷酸鸟苷模拟了硝普钠对去甲肾上腺素、去氧肾上腺素、氯化钾和可乐定诱导的收缩的抑制作用。硝普钠和8-溴环磷酸鸟苷仅在初始静息膜电位较低的标本中增加静息膜电位。在先前用去甲肾上腺素、氯化钾和可乐定收缩和去极化的组织中，硝普钠和8-溴环磷酸鸟苷均引起舒张，而对膜电位无明显影响。硝普钠和8-溴环磷酸鸟苷均消除神经介导的收缩，而对电反应无任何明显影响。这些结果表明，硝普钠和8-溴环磷酸鸟苷的作用与膜超极化或膜兴奋性抑制无关。
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