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Inhibition of cGMP-dependent protein kinase by the cell-permeable peptide DT-2 reveals a novel mechanism of vasoregulation.细胞可渗透肽DT-2对环磷酸鸟苷依赖性蛋白激酶的抑制揭示了一种新的血管调节机制。
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Regulation of intracellular Ca2+ and calcineurin by NO/PKG in proliferation of vascular smooth muscle cells.一氧化氮/蛋白激酶G对血管平滑肌细胞增殖过程中细胞内钙离子及钙调神经磷酸酶的调控
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Inhibition of cyclic GMP-dependent protein kinase-mediated effects by (Rp)-8-bromo-PET-cyclic GMPS.（Rp）-8-溴-PET-环鸟苷单磷酸对环鸟苷单磷酸依赖性蛋白激酶介导的效应的抑制作用
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本文引用的文献

1
Defective nitrovasodilator-stimulated protein phosphorylation and calcium regulation in cGMP-dependent protein kinase-deficient human platelets of chronic myelocytic leukemia.慢性粒细胞白血病患者cGMP依赖性蛋白激酶缺陷的人血小板中硝基血管扩张剂刺激的蛋白磷酸化和钙调节存在缺陷。
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Effects of cyclic AMP and analogues on neurogenic transmission in the rat tail artery.环磷酸腺苷及其类似物对大鼠尾动脉神经源性传递的影响。
Br J Pharmacol. 1994 Feb;111(2):625-31. doi: 10.1111/j.1476-5381.1994.tb14782.x.
3
The nitric oxide and cGMP signal transduction system: regulation and mechanism of action.一氧化氮与环鸟苷酸信号转导系统：调节与作用机制
Biochim Biophys Acta. 1993 Aug 18;1178(2):153-75. doi: 10.1016/0167-4889(93)90006-b.
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Some statistical methods useful in circulation research.一些在循环研究中有用的统计方法。
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Effect of cGMP derivatives on contraction relaxation cycle, release of norepinephrine and protein kinase activity in guinea pig vas deferens.环磷酸鸟苷衍生物对豚鼠输精管收缩舒张周期、去甲肾上腺素释放及蛋白激酶活性的影响。
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The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine.内皮细胞在乙酰胆碱介导的动脉平滑肌舒张中所起的不可或缺的作用。
Nature. 1980 Nov 27;288(5789):373-6. doi: 10.1038/288373a0.
7
Atrial natriuretic factor elicits an endothelium-independent relaxation and activates particulate guanylate cyclase in vascular smooth muscle.心钠素可引起不依赖内皮的舒张反应，并激活血管平滑肌中的颗粒型鸟苷酸环化酶。
Proc Natl Acad Sci U S A. 1984 Dec;81(23):7661-4. doi: 10.1073/pnas.81.23.7661.
8
Regulation of cyclic GMP formation by soluble guanylate cyclase: stimulation by NO-containing compounds.可溶性鸟苷酸环化酶对环鸟苷酸形成的调节：含一氧化氮化合物的刺激作用。
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9
Involvement of cyclic nucleotides in prejunctional modulation of noradrenaline release in mouse atria.环核苷酸参与小鼠心房去甲肾上腺素释放的突触前调节。
Br J Pharmacol. 1987 Aug;91(4):773-81. doi: 10.1111/j.1476-5381.1987.tb11275.x.
10
Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor.一氧化氮的释放构成了内皮源性舒张因子的生物活性。
Nature. 1987;327(6122):524-6. doi: 10.1038/327524a0.

环磷酸鸟苷及其类似物对大鼠尾动脉神经源性传递的影响。

Effects of cyclic GMP and analogues on neurogenic transmission in the rat tail artery.

作者信息

Ouedraogo S, Tschöpl M, Stoclet J C, Bucher B

机构信息

Laboratoire de Pharmacologie Cellulaire et Moléculaire, C.N.R.S., URA 600, Université Louis Pasteur Strasbourg, Illkirch, France.

出版信息

Br J Pharmacol. 1994 Jul;112(3):867-72. doi: 10.1111/j.1476-5381.1994.tb13160.x.

DOI:10.1111/j.1476-5381.1994.tb13160.x
PMID:7921614
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1910191/
Abstract
  1. The effects of membrane permeable analogues of guanosine 3':5'-cyclic monophosphate (cyclic GMP), and of the NO donor, 3-morpholinosydnonimine-N-ethylcarbamide (SIN-1) were investigated on [3H]-noradrenaline release and neurogenic vasoconstriction in electrical field stimulated rat tail arteries. 2. Two 8-substituted analogues of cyclic GMP (8-bromoguanosine 3':5'-cyclic monophosphate; 8-bromo-cyclic GMP and 8-(4-chlorophenylthio)-guanosine 3':5'-cyclic monophosphate; 8-pCPT-cyclic GMP) concentration-dependently enhanced stimulation-induced [3H]-noradrenaline release. These prejunctional effects were antagonized by the cyclic AMP-dependent protein kinase (PKA) inhibitor N-[2-((3-(4-bromophenyl)-2-propenyl)-amino)-ethyl]-5 isoquinolinesulphonamide dihydrochloride (H-89; 100 nM) but not by the cyclic GMP-dependent protein kinase (PKG) inhibitors, Rp-8-bromoguanosine 3':5'-cyclic monophosphorothioate (Rp-8-bromo-cyclic GMPS; 10 microM) or Rp-8-(4-chlorophenylthio)-guanosine 3':5'-cyclic monophosphorothioate (Rp-8-pCPT-cyclic GMPS; 10 microM). 3. beta-Phenyl-1,N2-ethenoguanosine 3':5'-cyclic monophosphate (PET-cyclic GMP) had no effect on stimulation-induced [3H]-noradrenaline release but concentration-dependently decreased the stimulation-induced vasoconstriction. 4. The two 8-substituted cyclic GMP derivatives, PET-cyclic GMP and SIN-1, both decreased stimulation-induced vasoconstriction. In addition, SIN-1 relaxed rat tail arteries precontracted with phenylephrine (1 microM). The SIN-1 concentration-relaxation curve was shifted in parallel manner to the right by Rp-8-bromo-cyclic GMPS (10 microM) and Rp-8-pCPT-cyclic GMPS (10 microM) with no change in the maximum effect, showing that the relaxation was mediated by a cyclic GMP/PKG-dependent mechanism. 5. It is concluded that PKA activation is involved in the noradrenaline release enhancing effect of the two 8-substituted cyclic GMP analogues, whereas a cyclic GMP/PKG-operated pathway accounts for the inhibitory effects of the cyclic GMP and its analogues on vascular smooth muscle contraction.
摘要
  1. 研究了鸟苷3':5'-环一磷酸（环磷酸鸟苷，cGMP）的膜通透性类似物以及一氧化氮供体3-吗啉代亚硝基胍-N-乙基脲（SIN-1）对电场刺激大鼠尾动脉中[3H]-去甲肾上腺素释放和神经源性血管收缩的影响。2. 两种cGMP的8-取代类似物（8-溴鸟苷3':5'-环一磷酸；8-溴-cGMP和8-(4-氯苯硫基)-鸟苷3':5'-环一磷酸；8-pCPT-cGMP）浓度依赖性地增强刺激诱导的[3H]-去甲肾上腺素释放。这些突触前效应被环磷酸腺苷依赖性蛋白激酶（PKA）抑制剂N-[2-((3-(4-溴苯基)-2-丙烯基)-氨基)-乙基]-5-异喹啉磺酰胺二盐酸盐（H-89；100 nM）拮抗，但不被环磷酸鸟苷依赖性蛋白激酶（PKG）抑制剂Rp-8-溴鸟苷3':5'-环一磷酸硫代磷酸酯（Rp-8-溴-cGMPS；10 μM）或Rp-8-(4-氯苯硫基)-鸟苷3':5'-环一磷酸硫代磷酸酯（Rp-8-pCPT-cGMPS；10 μM）拮抗。3. β-苯基-1,N2-乙烯基鸟苷3':5'-环一磷酸（PET-cGMP）对刺激诱导的[3H]-去甲肾上腺素释放无影响，但浓度依赖性地降低刺激诱导的血管收缩。4. 两种8-取代的环磷酸鸟苷衍生物、PET-cGMP和SIN-1均降低刺激诱导的血管收缩。此外，SIN-1使预先用去氧肾上腺素（1 μM）预收缩的大鼠尾动脉舒张。SIN-1的浓度-舒张曲线被Rp-8-溴-cGMPS（10 μM）和Rp-8-pCPT-cGMPS（10 μM）平行向右移动，最大效应无变化，表明舒张是由环磷酸鸟苷/蛋白激酶G依赖性机制介导的。5. 结论是，PKA激活参与了两种8-取代环磷酸鸟苷类似物增强去甲肾上腺素释放的作用，而环磷酸鸟苷/蛋白激酶G介导的途径解释了环磷酸鸟苷及其类似物对血管平滑肌收缩的抑制作用。