Department of Clinical Biochemistry, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran.
Department of Clinical Biochemistry, Faculty of Medicine, Shahid Beheshti University of Medical sciences, Tehran, Iran.
Biomed Pharmacother. 2018 Oct;106:239-246. doi: 10.1016/j.biopha.2018.06.131. Epub 2018 Jun 28.
Cancer is one of the most dangerous diseases that are rapidly increasing globally. After heart disease, it is the second leading cause of death, accounting for seven million deaths each year. Chemotherapy is the use of cytotoxic drugs on cancer cells. But the use of common chemotherapy drugs poses a problem due their high side effects and low efficacy. As a result, efforts are on to find new potent compounds with low side effects. The compounds extracted from plants have been studied in this regard due to their prevalence. Sesquiterpene lactones are a group of natural compounds that were first detected in Asteraceae dark plants. These compounds exercise their effects by reacting with functional groups available on proteins and enzymes, especially the thiol group. Owing to the high side effects as an antitumor synthetic drugs, efforts are being made to find drugs with high efficiency and low side effects. Their high structural ranges have attracted the attention of many researchers as a potential source of new anticancer drugs.
癌症是一种在全球迅速增长的最危险疾病之一。心脏病之后，它是第二大死亡原因，每年导致 700 万人死亡。化疗是使用细胞毒性药物治疗癌细胞。但是，由于普通化疗药物的副作用高、疗效低，因此使用它们存在问题。因此，人们正在努力寻找具有低副作用的新型有效化合物。由于其普遍性，已经在这方面研究了从植物中提取的化合物。倍半萜内酯是一组天然化合物，最初在菊科深色植物中被检测到。这些化合物通过与蛋白质和酶上可用的功能基团（特别是巯基）反应来发挥作用。由于作为抗肿瘤合成药物的高副作用，人们正在努力寻找高效低副作用的药物。它们的高结构范围引起了许多研究人员的关注，认为它们是潜在的新型抗癌药物的来源。
