From the Research Division of the Scripps Translational Science Institute, The Scripps Research Institute, La Jolla, CA (B.D.M., N.N., N.P., D.M.D., G.E., E.J.T., S.S.)
Division of Digital Health, Withings, Paris, France (O.B., A.C.).
Hypertension. 2018 Aug;72(2):503-510. doi: 10.1161/HYPERTENSIONAHA.118.11177. Epub 2018 Jul 2.
Cardiovascular disease remains the leading cause of death and disease worldwide. As demands on an already resource-constrained healthcare system intensify, disease prevention in the future will likely depend on out-of-office monitoring of cardiovascular risk factors. Mobile health tracking devices that can track blood pressure and heart rate, in addition to new cardiac vital signs, such as physical activity level and pulse wave velocity (PWV), offer a promising solution. An initial barrier is the development of accurate and easily-scalable platforms. In this study, we made a customized smartphone app and used mobile health devices to track PWV, blood pressure, heart rate, physical activity, sleep duration, and multiple lifestyle risk factors in ≈250 adults for 17 continual weeks. Eligible participants were identified by a company database and then were consented and enrolled using only a smartphone app, without any special training given. Study participants reported high overall satisfaction, and 73% of participants were able to measure blood pressure and PWV, <1 hour apart, for at least 14 of 17 weeks. The study population's blood pressure, PWV, heart rate, activity levels, sleep duration, and the interrelationships among these measurements were found to closely match either population averages or values obtained from studies performed in a controlled setting. As a proof-of-concept, we demonstrated the accuracy and ease, as well as many challenges, of using mHealth technology to accurately track PWV and new cardiovascular vital signs at home.
心血管疾病仍然是全球范围内导致死亡和疾病的主要原因。随着对医疗保健系统资源的需求不断增加,未来的疾病预防可能依赖于对心血管危险因素的非办公场所监测。除了新的心脏生命体征(如身体活动水平和脉搏波速度(PWV))外,能够监测血压和心率的移动健康跟踪设备为这一问题提供了一个有前景的解决方案。一个初始的障碍是开发准确且易于扩展的平台。在这项研究中,我们开发了一个定制的智能手机应用程序,并使用移动健康设备来跟踪 PWV、血压、心率、身体活动、睡眠时长和多个生活方式危险因素,持续了 17 周,参与者约有 250 名成年人。符合条件的参与者通过公司数据库进行识别,然后仅使用智能手机应用程序进行同意和招募,而无需提供任何特殊培训。研究参与者报告了总体满意度高,其中 73%的参与者能够在至少 14 周的时间内,每 1 小时测量 1 次血压和 PWV。研究人群的血压、PWV、心率、活动水平、睡眠时长以及这些测量值之间的相互关系与人群平均值或在受控环境中进行的研究中获得的值非常匹配。作为概念验证,我们展示了使用移动健康技术在家中准确跟踪 PWV 和新的心血管生命体征的准确性、易用性以及许多挑战。