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新兴治疗策略在心血管疾病管理中的应用综述

Review on Emerging Therapeutic Strategies for Managing Cardiovascular Disease.

机构信息

SMBT College of Pharmacy, Nandi Hills Dhamangaon Taluka Igatpuri, Nashik 422403, India.

出版信息

Curr Cardiol Rev. 2024;20(4):e160424228949. doi: 10.2174/011573403X299265240405080030.

Abstract

Cardiovascular disease (CVD) remains a foremost global health concern, necessitating ongoing exploration of innovative therapeutic strategies. This review surveys the latest developments in cardiovascular therapeutics, offering a comprehensive overview of emerging approaches poised to transform disease management. The examination begins by elucidating the current epidemiological landscape of CVD and the economic challenges it poses to healthcare systems. It proceeds to scrutinize the limitations of traditional therapies, emphasizing the need for progressive interventions. The core focus is on novel pharmacological interventions, including advancements in drug development, targeted therapies, and repurposing existing medications. The burgeoning field of gene therapy and its potential in addressing genetic predispositions to cardiovascular disorders are explored, alongside the integration of artificial intelligence and machine learning in risk assessment and treatment optimization. Non-pharmacological interventions take center stage, with an exploration of digital health technologies, wearable devices, and telemedicine as transformative tools in CVD management. Regenerative medicine and stem cell therapies, offering promises of tissue repair and functional recovery, are investigated for their potential impact on cardiac health. This review also delves into the interplay of lifestyle modifications, diet, exercise, and behavioral changes, emphasizing their pivotal role in cardiovascular health and disease prevention. As precision medicine gains prominence, this synthesis of emerging therapeutic modalities aims to guide clinicians and researchers in navigating the dynamic landscape of cardiovascular disease management, fostering a collective effort to alleviate the global burden of CVD and promote a healthier future.

摘要

心血管疾病 (CVD) 仍然是全球首要的健康关注点,需要不断探索创新的治疗策略。本综述调查了心血管治疗学的最新进展,全面概述了有望改变疾病管理的新兴方法。

首先,我们阐明了 CVD 的当前流行病学现状及其对医疗体系带来的经济挑战。然后,我们审视了传统疗法的局限性,强调需要进行渐进式干预。重点关注新型药物治疗干预,包括药物开发、靶向治疗和现有药物再利用方面的进展。探讨了基因治疗领域的新兴发展及其在解决心血管疾病遗传易感性方面的潜力,以及人工智能和机器学习在风险评估和治疗优化中的整合。非药物干预措施占据核心地位,探讨了数字健康技术、可穿戴设备和远程医疗在 CVD 管理中的变革性作用。还研究了再生医学和干细胞疗法,它们为组织修复和功能恢复提供了希望,探讨了它们对心脏健康的潜在影响。

本综述还深入探讨了生活方式改变、饮食、运动和行为改变的相互作用,强调它们在心血管健康和疾病预防中的关键作用。随着精准医学的兴起,这种新兴治疗模式的综合旨在为临床医生和研究人员提供指导,帮助他们应对心血管疾病管理的动态领域,共同努力减轻 CVD 的全球负担,促进更健康的未来。

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