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Neuropeptide Y reduces orthodromically evoked population spike in rat hippocampal CA1 by a possibly presynaptic mechanism.

作者信息

Colmers W F, Lukowiak K, Pittman Q J

出版信息

Brain Res. 1985 Nov 4;346(2):404-8. doi: 10.1016/0006-8993(85)90880-7.

DOI:10.1016/0006-8993(85)90880-7
PMID:2996711
Abstract

Application of the brain neuropeptide Y (NPY) to rat hippocampus in vitro reversibly reduced the amplitude of the CA1 population spike evoked by stratum radiatum stimulation. Threshold for the effect was 10(-8) M. NPY had similar effects on single pulse- and paired pulse-evoked population spikes. Antidromic population spikes, evoked from the alveus, were unaffected by NPY. Thus, NPY appears to modulate excitatory transmission in the hippocampus by a presynaptic mechanism.

摘要

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Br J Pharmacol. 1988 Dec;95(4):1117-24. doi: 10.1111/j.1476-5381.1988.tb11746.x.

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