Diplotype analysis of NUDT15 variants and 6-mercaptopurine sensitivity in pediatric lymphoid neoplasms.
作者信息
Tsujimoto Shinichi, Osumi Tomoo, Uchiyama Meri, Shirai Ryota, Moriyama Takaya, Nishii Rina, Yamada Yuji, Kudo Ko, Sekiguchi Masahiro, Arakawa Yuki, Yoshida Masanori, Uchiyama Toru, Terui Kiminori, Ito Shuichi, Koh Katsuyoshi, Takita Junko, Ito Etsuro, Tomizawa Daisuke, Manabe Atsushi, Kiyokawa Nobutaka, Yang Jun J, Kato Motohiro
机构信息
Department of Pediatric Hematology and Oncology Research, National Research Institute for Child Health and Development, Tokyo, Japan.
Department of Pediatrics, Yokohama City University, Yokohama, Japan.
出版信息
Leukemia. 2018 Dec;32(12):2710-2714. doi: 10.1038/s41375-018-0190-1. Epub 2018 Jul 2.
Abstract
摘要
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Treatment and biology of pediatric acute lymphoblastic leukemia.儿童急性淋巴细胞白血病的治疗与生物学
Pediatr Int. 2018 Jan;60(1):4-12. doi: 10.1111/ped.13457.
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Novel variants in and thiopurine intolerance in children with acute lymphoblastic leukemia from diverse ancestry.不同血统急性淋巴细胞白血病患儿中与硫嘌呤不耐受相关的新变异体。
Blood. 2017 Sep 7;130(10):1209-1212. doi: 10.1182/blood-2017-05-782383. Epub 2017 Jun 28.
3
Most T790M mutations are present on the same EGFR allele as activating mutations in patients with non-small cell lung cancer.在非小细胞肺癌患者中，大多数T790M突变与激活突变位于同一个表皮生长因子受体（EGFR）等位基因上。
Lung Cancer. 2017 Jun;108:75-82. doi: 10.1016/j.lungcan.2017.02.019. Epub 2017 Mar 1.
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Combined Detection of NUDT15 Variants Could Highly Predict Thiopurine-induced Leukopenia in Chinese Patients with Inflammatory Bowel Disease: A Multicenter Analysis.联合检测 NUDT15 变异可高度预测中国炎症性肠病患者硫嘌呤诱导的白细胞减少症：一项多中心分析。
Inflamm Bowel Dis. 2017 Sep;23(9):1592-1599. doi: 10.1097/MIB.0000000000001148.
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The effects of inherited NUDT15 polymorphisms on thiopurine active metabolites in Japanese children with acute lymphoblastic leukemia.遗传性NUDT15基因多态性对日本急性淋巴细胞白血病儿童硫嘌呤活性代谢物的影响。
Pharmacogenet Genomics. 2017 Jun;27(6):236-239. doi: 10.1097/FPC.0000000000000282.
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DNA-thioguanine nucleotide concentration and relapse-free survival during maintenance therapy of childhood acute lymphoblastic leukaemia (NOPHO ALL2008): a prospective substudy of a phase 3 trial.儿童急性淋巴细胞白血病维持治疗期间的 DNA-硫鸟嘌呤核苷酸浓度与无病生存（NOPHO ALL2008）：一项 3 期试验的前瞻性亚研究。
Lancet Oncol. 2017 Apr;18(4):515-524. doi: 10.1016/S1470-2045(17)30154-7. Epub 2017 Mar 1.
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TPMT and NUDT15 genes are both related to mercaptopurine intolerance in acute lymphoblastic leukaemia patients from Uruguay.TPMT和NUDT15基因均与乌拉圭急性淋巴细胞白血病患者对巯嘌呤的不耐受性有关。
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Long-term outcome of 6-month maintenance chemotherapy for acute lymphoblastic leukemia in children.儿童急性淋巴细胞白血病 6 个月维持化疗的长期结果。
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NUDT15 and TPMT genetic polymorphisms are related to 6-mercaptopurine intolerance in children treated for acute lymphoblastic leukemia at the Children's Cancer Center of Lebanon.NUDT15和TPMT基因多态性与黎巴嫩儿童癌症中心接受急性淋巴细胞白血病治疗的儿童对6-巯基嘌呤不耐受有关。
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NUDT15 polymorphisms alter thiopurine metabolism and hematopoietic toxicity.NUDT15基因多态性改变硫嘌呤代谢及造血毒性。
Nat Genet. 2016 Apr;48(4):367-73. doi: 10.1038/ng.3508. Epub 2016 Feb 15.
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