Epstein-Barr virus activation by human semen principle: synergistic effect of culture fluids of bacteria isolated from patients with carcinoma of uterine cervix.

Epstein-Barr virus early antigens (EBV EA) were induced in a Raji cell system in order to assay the activity of the EA inducer in human semen. In semen from 53 Chinese, 45.3% induced EBV EA in Raji cells. Such positive semen and EBV-inducing positive culture fluids of bacteria isolated from the uterine cervix of patients with cervical carcinoma had a synergistic effect on the induction of EBV EA. This synergistic effect as related to the cause of cervical carcinoma is discussed.