Chao David T, Shah Nilesh H, Zeh Herbert J, Singhi Aatur D, Bahary Nathan, McGrath Kevin M, Fasanella Kenneth E, Zureikat Amer H, Whitcomb David C, Brand Randall E
Department of Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
Division of Gastroenterology and Hepatology, Kaiser Permanente, Los Angeles Medical Center, Los Angeles, CA, USA.
Gastroenterol Res Pract. 2018 Jun 5;2018:2380596. doi: 10.1155/2018/2380596. eCollection 2018.
Adolescent obesity is a national epidemic that recently has been shown to increase risk for pancreatic adenocarcinoma (PC) and is associated with an earlier age of PC onset. We hypothesized that PC patients who are overweight or obese at age 18 would have an earlier age of PC onset.
Retrospective review of 531 patients in our PC registry was completed. Self-reported weight at age 18 and maximum lifetime weight were used to calculate body mass index (BMI) at age 18 (BMI-18) and maximum lifetime BMI.
Complete BMI and baseline covariate data was available in 319 PC patients. Mean age (in years) of PC diagnosis for patients whose BMI-18 was overweight (64.0) or obese (59.9) was significantly different when compared to patients with a normal BMI-18 (66.7). No significant difference was observed in the mean age of PC diagnosis in those patients who maintained a normal BMI-18 when compared to those patients who subsequently became overweight or obese (67.0 versus 66.6; = 0.65).
An elevated BMI at age 18 is associated with an earlier age of PC onset and should be factored into determining the optimal age of beginning screening for patients at high risk for PC.
青少年肥胖是一种全国性的流行病，最近的研究表明其会增加胰腺腺癌（PC）的发病风险，且与PC发病年龄提前有关。我们推测18岁时超重或肥胖的PC患者发病年龄会更早。
对我们PC登记册中的531例患者进行了回顾性研究。使用18岁时自我报告的体重和最大终身体重来计算18岁时的体重指数（BMI-18）和最大终身BMI。
319例PC患者有完整的BMI和基线协变量数据。BMI-18超重（64.0岁）或肥胖（59.9岁）的患者与BMI-18正常的患者（66.7岁）相比，PC诊断的平均年龄有显著差异。与随后超重或肥胖的患者相比，BMI-18维持正常的患者在PC诊断的平均年龄上没有显著差异（67.0岁对66.6岁；P = 0.65）。
18岁时BMI升高与PC发病年龄较早有关，在确定PC高危患者开始筛查的最佳年龄时应予以考虑。
