Wang Linda X, Gurka Matthew J, Deboer Mark D
Department of Pediatrics, University of Virginia, Charlottesville, VA, USA.
Department of Health Outcomes and Biomedical Informatics, College of Medicine, University of Florida, Gainesville, FL, USA.
Minerva Pediatr. 2018 Oct;70(5):467-475. doi: 10.23736/S0026-4946.18.05290-8. Epub 2018 Jul 2.
The continued rise of pediatric obesity globally has raised concerns for related sequalae. One marker of risk is the metabolic syndrome, a cluster of cardiovascular risk factors that is associated with future cardiovascular disease and type 2 diabetes. MetS has at its core visceral adipocytes exhibiting dysfunction as a result of excess fat content. MetS in children and adolescents is linked to unhealthy lifestyle practices such as sedentary lifestyles and excess consumption calories. As such, the optimal means of addressing MetS is targeting a decrease in adiposity through lifestyle modification, a decrease in MetS following increases in physical activity and improvements in the quality and content of food intake. Efforts remain needed in increasing motivation to these changes and maintaining adherence to avoid long-term sequelae.
全球儿童肥胖率的持续上升引发了对相关后遗症的担忧。风险的一个标志是代谢综合征，这是一组心血管危险因素，与未来的心血管疾病和2型糖尿病有关。代谢综合征的核心是内脏脂肪细胞因脂肪含量过多而出现功能障碍。儿童和青少年的代谢综合征与久坐不动的生活方式和热量摄入过多等不健康的生活习惯有关。因此，解决代谢综合征的最佳方法是通过改变生活方式来降低肥胖率，通过增加身体活动和改善食物摄入的质量和内容来降低代谢综合征。在增加对这些改变的动力和保持依从性以避免长期后遗症方面仍需努力。
