Rama Krishna Boddu, Ramakrishna Sistla, Rajendra Sangaraju, Madhusudana Kuncha, Mallavadhani Uppuluri Venkata
Natural Products Chemistry Division, CSIR-Indian Institute of Chemical Technology , Hyderabad 500007 , India.
Academy of Scientific and Innovative Research (AcSIR), CSIR-Indian Institute of Chemical Technology , Hyderabad 500007 , India.
J Asian Nat Prod Res. 2019 Oct;21(10):1013-1027. doi: 10.1080/10286020.2018.1490274. Epub 2018 Jul 3.
Sixteen novel orsellinic esters () along with four lecanoric acid related depsides (3) were synthesized and confirmed their structures by spectroscopic data (H, C & HRMS). The synthesized compounds were evaluated for their -glucosidase () inhibitory potential. Among the tested compounds, (IC: 140.9 μM) and (IC: 203.9 μM) displayed potent α-glucosidase inhibitory activity and found more active than the standard drug acarbose (IC: 686.6 μM). Both the test compounds were subjected to antihyperglycemic activity using sucrose loaded model in Wistar rats and found compound exhibited significant reduction in glucose levels.
合成了16种新型苔色酸酯（）以及4种与黑茶渍素相关的缩酚酸（3），并通过光谱数据（H、C和HRMS）确认了它们的结构。对合成的化合物进行了α-葡萄糖苷酶（）抑制潜力的评估。在测试的化合物中，（IC：140.9 μM）和（IC：203.9 μM）表现出较强的α-葡萄糖苷酶抑制活性，且比标准药物阿卡波糖（IC：686.6 μM）更具活性。使用Wistar大鼠的蔗糖负荷模型对这两种测试化合物进行了抗高血糖活性研究，发现化合物使血糖水平显著降低。
