血色素沉着症（HFE）基因变异与HIV-1感染及抗逆转录病毒治疗期间线粒体DNA水平升高有关。
Hemochromatosis (HFE) Gene Variants Are Associated with Increased Mitochondrial DNA Levels During HIV-1 Infection and Antiretroviral Therapy.
作者信息
Kallianpur Asha R, Gerschenson Mariana, Hulgan Todd, Kaur Harpreet, Clifford David B, Haas David W, Murdock Deborah G, McArthur Justin C, Samuels David C, Simpson David M
机构信息
1 Department of Genomic Medicine, Cleveland Clinic Foundation/Lerner Research Institute , Cleveland, Ohio.
2 Department of Molecular Medicine, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University , Cleveland, Ohio.
出版信息
AIDS Res Hum Retroviruses. 2018 Nov;34(11):942-949. doi: 10.1089/AID.2018.0025. Epub 2018 Aug 22.
Some HIV-associated complications involve mitochondrial dysfunction and may be less common in individuals with iron-loading HFE (hemochromatosis gene) variants. We evaluated HFE 845A and 187G alleles in relation to mitochondrial DNA (mtDNA) levels in peripheral blood mononuclear cells from 85 individuals with HIV infection on uninterrupted antiretroviral therapy (ART) for 15 or more consecutive weeks. Carriers of HFE gene variants (N = 24) had significantly higher mtDNA levels than noncarriers (N = 61), after adjusting for age, race, sex, and type of ART [adjusted β-coefficient 297, p-value < .001 for at least one HFE variant], but mtDNA declined among all individuals on study during 48 weeks on ART. Increased cellular mtDNA content may represent a compensatory response to mitochondrial stress that is influenced by iron-loading HFE variants.
一些与HIV相关的并发症涉及线粒体功能障碍，在携带铁过载HFE（血色素沉着病基因）变体的个体中可能不太常见。我们评估了85名接受连续15周或更长时间不间断抗逆转录病毒治疗（ART）的HIV感染者外周血单核细胞中HFE 845A和187G等位基因与线粒体DNA（mtDNA）水平的关系。在调整年龄、种族、性别和ART类型后，HFE基因变体携带者（N = 24）的mtDNA水平显著高于非携带者（N = 61）[至少一种HFE变体的调整β系数为297，p值<0.001]，但在接受48周ART治疗期间，所有研究对象的mtDNA均下降。细胞mtDNA含量增加可能代表对线粒体应激的一种代偿反应，这种反应受铁过载HFE变体的影响。
Zotero 插件