Department of Orthopaedics, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510150, China.
Department of Orthopaedics, China-Japan Friendship Hospital, Beijing, 100029, China.
Sci Rep. 2018 Jul 3;8(1):9988. doi: 10.1038/s41598-018-28433-7.
This study investigatedthe different effects of long-term glucocorticoid (GC) interventions on the microarchitectures of cortical and cancellous bones of the femoral head. Eighteen female skeletal mature sheep were randomly allocated into 3 groups, 6 each. Group 1 received prednisolone interventions (0.60 mg/kg/day, 5 times weekly) for 7 months. Group 2 received the same interventions as Group 1 and then further observed 3 months without interventions. Control Group was left nonintervention. After killing the animals, all femoral heads were scanned by micro-CT to determine their microstructural properties. In cancellous bone of femoral head, GC interventions led to significant decrease of bone volume fraction, trabecular thickness, trabecular separation, but increase of structure model index and bone surface density (p < 0.05). While in cortical bone, there were no differences between the Group 1 and in microstructural properties (p > 0.05) except greater trabecular thickness in the control group. In addition, three months after cessation of glucocorticoid interventions, most microstructural properties of cancellous bone were significant reversed, but not cortical thickness of femoral head. In contrast to cancellous bone, the microarchitectures of cortical bone were not changed obviously after long-term GC interventions.
本研究探讨了长期糖皮质激素（GC）干预对股骨头皮质骨和松质骨微观结构的不同影响。18 只骨骼成熟的雌性绵羊被随机分为 3 组，每组 6 只。第 1 组接受泼尼松龙干预（0.60mg/kg/天，每周 5 次）7 个月。第 2 组接受与第 1 组相同的干预，然后再观察 3 个月无干预。对照组不进行干预。处死动物后，所有股骨头均通过 micro-CT 扫描以确定其微观结构特性。在股骨头的松质骨中，GC 干预导致骨体积分数、骨小梁厚度、骨小梁分离显著减少，但结构模型指数和骨表面密度增加（p<0.05）。而在皮质骨中，除了对照组的骨小梁厚度较大外，第 1 组与骨微观结构特性之间没有差异（p>0.05）。此外，停止糖皮质激素干预三个月后，松质骨的大多数微观结构特性显著逆转，但股骨头的皮质厚度没有变化。与松质骨相比，长期 GC 干预后皮质骨的微观结构没有明显变化。
