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中脑边缘多巴胺损伤会增强对脑啡肽的行为反应。

Mesolimbic dopamine lesions produce an augmented behavioral response to enkephalin.

作者信息

Kalivas P W, Bronson M

出版信息

Neuropharmacology. 1985 Oct;24(10):931-6. doi: 10.1016/0028-3908(85)90117-0.

DOI:10.1016/0028-3908(85)90117-0
PMID:3934576
Abstract

The mesolimbic dopamine (DA) system was lesioned by the injection of 6-hydroxydopamine into the nucleus accumbens or ventral tegmental area of rats. The rats were then examined in a photocell apparatus for their response to injection with the enkephalin analogue, D-Ala2-Met5-enkephalinamide (DALA), into the nucleus accumbens. Rats with DA lesions showed a significantly greater increase in photocell counts in response to DALA than did sham-lesioned animals. The potentiated motor response was dose-related, and rats having the greatest depletion of DA in the nucleus accumbens showed the greatest behavioral response to DALA. It was concluded that chronic impairment of dopaminergic innervation to the nucleus accumbens results in an enhanced response to DALA injected directly into the nucleus accumbens.

摘要

通过向大鼠伏隔核或腹侧被盖区注射6-羟基多巴胺来损伤中脑边缘多巴胺（DA）系统。然后在光电管装置中检查这些大鼠对向伏隔核注射脑啡肽类似物D-Ala2-Met5-脑啡肽酰胺（DALA）的反应。与假损伤动物相比，DA损伤的大鼠对DALA的反应表现出光电管计数显著更大的增加。增强的运动反应与剂量相关，伏隔核中DA耗竭最大的大鼠对DALA表现出最大的行为反应。得出的结论是，伏隔核多巴胺能神经支配的慢性损伤导致对直接注射到伏隔核中的DALA的反应增强。

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