基于连续流微波反应器的综合反应分析的快速反应条件优化。
Rapid Optimization of Reaction Conditions Based on Comprehensive Reaction Analysis Using a Continuous Flow Microwave Reactor.
机构信息
Applied Chemistry and Biochemical Engineering Course Department of Engineering, Graduate School of Integrated Science and Technology, Shizuoka University, 3-5-1 Johoku, Hamamatsu, Shizuoka, 432-8561, Japan.
Current address: Department of Organic Chemistry and Organic Chemical Technology, Budapest University of Technology and Economics, 1111, Budapest, Műegyetem rkp. 3, Hungary.
出版信息
Chem Rec. 2019 Jan;19(1):77-84. doi: 10.1002/tcr.201800048. Epub 2018 Jul 3.
Generally, the flow method has the advantage of a precise control over the reaction parameters and a facile modification of the reaction conditions, while a continuous flow microwave reactor allows for the quick optimization of reaction conditions owing to the rapid uniform heating. In this study, we developed a "9+4+1 method" to optimize reaction conditions based on comprehensive reaction analysis using a flow microwave reactor. The proposed method is expected to contribute to the synthesis of various fine and bulk chemicals by reducing cost and wastage, and by conserving time.
一般来说，流动方法具有精确控制反应参数和方便修改反应条件的优点，而连续流动微波反应器由于快速均匀加热，允许快速优化反应条件。在本研究中，我们开发了一种“9+4+1 方法”，通过使用流动微波反应器进行全面的反应分析来优化反应条件。该方法有望通过降低成本和浪费以及节省时间来促进各种精细和大宗化学品的合成。
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