微波对有机合成的影响以及连续流工艺和放大策略
Impact of Microwaves on Organic Synthesis and Strategies toward Flow Processes and Scaling Up.
作者信息
Martina Katia, Cravotto Giancarlo, Varma Rajender S
机构信息
Dipartimento di Scienza e Tecnologia del Farmaco and Centre for Nanostructured Interfaces and Surfaces (NIS), University of Turin, University of Turin, via P. Giuria 9, 10125 Turin, Italy.
Regional Centre of Advanced Technologies and Materials, Palacký University in Olomouc, Šlechtitelů 27, 783 71 Olomouc, Czech Republic.
出版信息
J Org Chem. 2021 Oct 15;86(20):13857-13872. doi: 10.1021/acs.joc.1c00865. Epub 2021 Jun 14.
Microwave-assisted organic synthesis has been widely studied and deliberated, opening up some controversial issues as well. Nowadays, microwave chemistry is a mature technology that has been well demonstrated in many cases with numerous advantages in terms of the reaction rate and yield. The strategies toward scaling up find an ally in continuous-flow reactor technology comparing dielectric and conductive heating.
微波辅助有机合成已得到广泛研究和探讨，同时也引发了一些有争议的问题。如今，微波化学是一项成熟的技术，在许多情况下都得到了充分证明，在反应速率和产率方面具有诸多优势。在比较介电加热和传导加热时，连续流动反应器技术为扩大规模的策略提供了助力。
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