Wang Chun-Meng, Tang Kai-Xiang, Gao Tian-Hong, Chen Lin, Sun Li-Ping
Jiangsu Key Laboratory of Drug Design & Optimization, Department of Medicinal Chemistry , China Pharmaceutical University , Nanjing 210009 , P. R. China.
J Org Chem. 2018 Aug 3;83(15):8315-8321. doi: 10.1021/acs.joc.8b01016. Epub 2018 Jul 13.
A novel protocol for the aromatic ortho C-H nitration of aryl ureas with Fe(NO)·9HO is developed. The reaction utilizes CuCl·2HO as catalyst and p-TSA as additive, showing good functional group tolerance and furnishing the desired products in moderate to excellent yields.
开发了一种用Fe(NO)·9H₂O对芳基脲进行芳香邻位C-H硝化的新方案。该反应以CuCl·2H₂O为催化剂，对甲苯磺酸为添加剂，具有良好的官能团耐受性，能以中等至优异的产率得到所需产物。
