Ma Weihao, Tyler McBride J, Phillips Robert S
Department of Chemistry, University of Georgia, Athens 30602, Georgia.
Department of Biochemistry and Molecular Biology, University of Georgia, Athens 30602, Georgia.
Tetrahedron Lett. 2025 Apr 15;159. doi: 10.1016/j.tetlet.2025.155515. Epub 2025 Mar 3.
Nitroarenes are critically important in medicinal chemistry, material science, and the chemical industry. In this paper, we introduce a new strategy for the electrophilic nitration of deactivated aromatic compounds, utilizing lithium nitrate (LiNO) in the presence of sulfuric acid in trifluoroacetic acid. This method has demonstrated moderate to excellent yield. Mild reaction conditions and easy workup make the synthesis of nitro compounds both practical and commercially feasible.
硝基芳烃在药物化学、材料科学和化学工业中至关重要。在本文中，我们介绍了一种用于钝化芳香族化合物亲电硝化的新策略，即在三氟乙酸中硫酸存在下使用硝酸锂（LiNO）。该方法已证明产率适中至优异。温和的反应条件和简便的后处理使得硝基化合物的合成既实用又具有商业可行性。
