Kommers D, Broeren M, Oei G, Feijs L, Andriessen P, Bambang Oetomo S
Department of Neonatology, Máxima Medical Centre Veldhoven, The Netherlands; Department of Applied Physics, Eindhoven University of Technology, The Netherlands.
Clinical Chemistry Laboratory, European Specialist in Laboratory Medicine, Máxima Medical Centre Veldhoven, The Netherlands.
Biol Psychol. 2018 Sep;137:18-23. doi: 10.1016/j.biopsycho.2018.06.009. Epub 2018 Jun 30.
To investigate whether Kangaroo care (KC) influences the salivary oxytocin (OT) concentration in preterm infants, and which correlates affect the OT response.
Eleven twin pairs participated in a study in which we collected saliva using cotton swabs twice a day, once during KC and once during baseline conditions (lying in bed or incubator). The total study duration was five days. The saliva of twin siblings were pooled to obtain vials with sufficient volumes of either saliva collected during KC or at baseline. OT levels were measured using a radio-immuno assay. The infants' state of comfort and parent-infant interaction were examined using previously developed Likert-scales, amongst other correlates such as the KC duration, gestational age and birth weight.
During KC, OT was lower compared to baseline (mean 1.39 pg/ml (SD 0.58 pg/ml) versus 2.40 pg/ml (SD 1.64 pg/ml), p = 0.03). Comfort at baseline and parent-infant interaction seemed to influence OT responses.
The OT concentration in the pooled saliva of preterm infant twins decreased during KC. This response of the OT system might be explained by stress during baseline.
探讨袋鼠式护理（KC）是否会影响早产儿唾液中催产素（OT）的浓度，以及哪些相关因素会影响OT反应。
11对双胞胎参与了一项研究，我们每天用棉签采集两次唾液，一次在进行KC期间，一次在基线状态下（躺在床上或在暖箱中）。研究总时长为5天。将双胞胎兄弟姐妹的唾液混合，以获得足够量的在KC期间或基线时采集的唾液样本瓶。使用放射免疫分析法测量OT水平。使用先前开发的李克特量表检查婴儿的舒适状态和亲子互动情况，以及其他相关因素，如KC持续时间、胎龄和出生体重。
与基线相比，KC期间OT水平较低（平均1.39 pg/ml（标准差0.58 pg/ml）对2.40 pg/ml（标准差1.64 pg/ml），p = 0.03）。基线时的舒适度和亲子互动似乎会影响OT反应。
早产儿双胞胎混合唾液中的OT浓度在KC期间降低。OT系统的这种反应可能是由基线时的应激所解释的。
