Serrano J S, Miñano F J, Sancibrián M, Durán J A
Gen Pharmacol. 1985;16(5):505-8. doi: 10.1016/0306-3623(85)90012-6.
GABA, delta-aminovaleric acid (DAVA) and sodium valproate (VPA) decrease core temperature in conscious rats. Bicuculline increases GABA-induced hypothermia, does not modify DAVA (250 mg/kg) and VPA (100 and 400 mg/kg) hypothermia and antagonizes initial hypothermia by DAVA (1000 mg/kg) and VPA (200 mg/kg) and late hypothermia by DAVA (500 mg/kg) and VPA (200 mg/kg). Picrotoxin increases late hypothermia by GABA (250 mg/kg) and VPA (400 mg/kg), but decreases initial hypothermia by VPA (200 mg/kg). Pentylenetetrazol increases variably GABA-induced hypothermia, inhibits early early hypothermia by DAVA and increases hypothermia induced by VPA (400 mg/kg). We conclude that GABA and GABA-agonists (DAVA and VPA) may induce hypothermia partly mediated by activation of bicuculline-insensitive GABA-receptors.
γ-氨基丁酸（GABA）、δ-氨基戊酸（DAVA）和丙戊酸钠（VPA）可降低清醒大鼠的核心体温。荷包牡丹碱可增强GABA诱导的体温过低，对DAVA（250毫克/千克）和VPA（100和400毫克/千克）诱导的体温过低无影响，并拮抗DAVA（1000毫克/千克）和VPA（200毫克/千克）引起的初始体温过低以及DAVA（500毫克/千克）和VPA（200毫克/千克）引起的后期体温过低。印防己毒素可增强GABA（250毫克/千克）和VPA（400毫克/千克）引起的后期体温过低，但可降低VPA（200毫克/千克）引起的初始体温过低。戊四氮对GABA诱导的体温过低的影响不一，可抑制DAVA引起的早期体温过低，并增强VPA（400毫克/千克）诱导的体温过低。我们得出结论，GABA和GABA激动剂（DAVA和VPA）可能通过激活对荷包牡丹碱不敏感的GABA受体，部分介导体温过低。
