Kim Dong Wook, Suh Junghwan, Kwon Ah Reum, Chae Hyun Wook, Yoon Choon Sik, Kim Ho-Seong, Kim Duk Hee
Department of Pediatrics, Yonsei University College of Medicine, Seoul, Korea.
Department of Radiology, Yonsei University College of Medicine, Seoul, Korea.
Ann Pediatr Endocrinol Metab. 2018 Jun;23(2):81-87. doi: 10.6065/apem.2018.23.2.81. Epub 2018 Jun 20.
This study aimed to investigate associations of central obesity with sexual maturation and metabolic parameters in Korean girls with precocious puberty.
This retrospective study evaluated data from 72 girls under 8 years of age with a chief complaint of early breast development. The patients were categorized as central precocious puberty (CPP) subjects or non-CPP subjects based on their gonadotropin-releasing hormone stimulation test results. Visceral fat thickness (VFT) was measured using ultrasonography and defined as the distance from the linea alba to the aorta. Patient anthropometric, metabolic, and hormonal parameters were also evaluated.
Increased VFT was correlated with an earlier onset of thelarche among all study subjects (r=-0.307, P=0.034). Overweight CPP subjects showed higher insulin resistance than normal weight CPP subjects. Insulin resistance was not significantly different between overweight and normal weight non-CPP subjects. VFT was not significantly different between CPP and non-CPP subjects (2.22±0.79 cm vs. 2.74±1.47 cm, P=0.169). However, overweight and obese CPP subjects (body mass index percentile>85%) had lower VFT than non-CPP obese subjects.
Central obesity, defined using ultrasonography-measured VFT, might be associated with early pubertal development in Korean girls. However, VFT was not higher in CPP than non-CPP patients and was not significantly correlated with insulin resistance. Further longitudinal studies with a larger cohort are needed.
本研究旨在调查韩国性早熟女孩中心性肥胖与性成熟及代谢参数之间的关联。
这项回顾性研究评估了72名8岁以下以乳房过早发育为主诉的女孩的数据。根据促性腺激素释放激素刺激试验结果，将患者分为中枢性性早熟（CPP）组和非CPP组。使用超声测量内脏脂肪厚度（VFT），定义为从白线到主动脉的距离。还评估了患者的人体测量、代谢和激素参数。
在所有研究对象中，VFT增加与乳房初发育的更早开始相关（r=-0.307，P=0.034）。超重的CPP患者比正常体重的CPP患者表现出更高的胰岛素抵抗。超重和正常体重的非CPP患者之间的胰岛素抵抗没有显著差异。CPP组和非CPP组之间的VFT没有显著差异（2.22±0.79厘米对2.74±1.47厘米，P=0.169）。然而，超重和肥胖的CPP患者（体重指数百分位数>85%）的VFT低于非CPP肥胖患者。
使用超声测量的VFT定义的中心性肥胖可能与韩国女孩青春期过早发育有关。然而，CPP患者的VFT并不高于非CPP患者，且与胰岛素抵抗无显著相关性。需要进行更大队列的进一步纵向研究。
