Unit of Nutrition, National Medical Center XXI Century, Instituto Mexicano del Seguro Social, Mexico City, Mexico.
Department of Pediatric Endocrinology. Hospital Infantil de México Federico Gómez, Ministry of Health (SSA), Mexico City, Mexico.
Peptides. 2018 Nov;109:9-13. doi: 10.1016/j.peptides.2018.09.009. Epub 2018 Sep 29.
To compare serum resistin concentrations between prepubertal girls with a BMI > 85th percentile and girls with precocious puberty (CPP) who have and have not undergone GnRH analog treatment.
This is a cross-sectional study in girls with a BMI > 85th percentile and a median age of 8 years. We included 31 girls with CPP who did not receive treatment (CPPoT), 23 girls with CPP who were treated with leuprolide (CPPT), 22 prepubertal girls and 24 pubertal girls. Anthropometric data and the fasting plasma concentrations of lipids, glucose, insulin, and resistin were measured.
The z-BMI scores were similar among the groups (p = 0.344), and body fat percentage (BF%) was similar among CPPT, CPPoT and prepubertal girls (p = 0.151). Resistin and insulin levels were lower in girls with CPP (CPPT and CPPoT) than in prepubertal and pubertal girls (median resistin level: CPPT 11.8 pg/ml vs CPPoT 11 pg/ml vs prepubertal 16 pg/ml vs pubertal 16 pg/ml, p = 0.001; median insulin level: CPPT 10.7 μUI/mL vs CPPoT 10.2 μUI/mL vs prepubertal 14.4 μUI/mL vs pubertal 32 μUI/mL p = 0.02). ANCOVA analysis, after adjustments for pubertal stage, BF% and z-BMI, showed that CPP modifies resistin levels (F = 31.4; p = 0.0001) independently of these parameters (p < 0.05).
In the group of girls with overweight or obesity, the resistin level was lower in girls with CPP than in prepubertal and pubertal girls. More studies are needed to understand the role of resistin in CPP patients.
比较血清抵抗素浓度在体重指数（BMI）大于第 85 百分位的青春期前女孩和性早熟（CPP）女孩之间的差异，这些女孩中又分为已经接受和未接受促性腺激素释放激素类似物（GnRH 类似物）治疗的 CPP 女孩。
这是一项横断面研究，纳入了 BMI 大于第 85 百分位且中位年龄为 8 岁的青春期前女孩。共纳入 31 例未接受治疗的 CPP 女孩（CPPoT）、23 例接受了亮丙瑞林治疗的 CPP 女孩（CPPT）、22 例青春期前女孩和 24 例青春期女孩。测量了女孩的人体测量数据和空腹血脂、血糖、胰岛素和抵抗素浓度。
各组间 z-BMI 评分相似（p=0.344），CPPT、CPPoT 和青春期前女孩的体脂百分比（BF%）相似（p=0.151）。CPP 女孩（CPPT 和 CPPoT）的抵抗素和胰岛素水平低于青春期前和青春期女孩（中位抵抗素水平：CPPT 11.8pg/ml 比 CPPoT 11pg/ml 比青春期前 16pg/ml 比青春期 16pg/ml，p=0.001；中位胰岛素水平：CPPT 10.7μUI/ml 比 CPPoT 10.2μUI/ml 比青春期前 14.4μUI/ml 比青春期 32μUI/ml，p=0.02）。经过青春期阶段、BF%和 z-BMI 的调整后，协方差分析显示 CPP 独立于这些参数改变了抵抗素水平（F=31.4；p=0.0001）（p<0.05）。
在超重或肥胖的青春期前女孩中，CPP 女孩的抵抗素水平低于青春期前和青春期女孩。需要更多的研究来了解抵抗素在 CPP 患者中的作用。
