Faculty of Agriculture , University of Miyazaki , 1-1 Gakuen Kibana-dai Nishi , Miyazaki 889-2192 , Japan.
Interdisciplinary Graduate School of Agriculture and Engineering , University of Miyazaki , 1-1 Gakuen Kibana-dai Nishi , Miyazaki 889-2192 , Japan.
J Agric Food Chem. 2018 Aug 1;66(30):7958-7964. doi: 10.1021/acs.jafc.8b02404. Epub 2018 Jul 18.
The effects of daily consumption of anthocyanins on bioavailability has remained unclear. In this study, we evaluated whether daily consumption affects the absorption rate of anthocyanins in rats when consumed during the active and sleep phase. Eighty rats were randomly divided into two groups. The first group consumed AIN-93G control diets, and the second group consumed AIN-93G diets containing 1% bilberry extract for 2 weeks. After 12 h fast, anthocyanins were not detected in plasma of rats. Bilberry extract (500 mg/kg body weight) was then orally administered at the beginning of the diurnal light period (ZT0, sleep phase) or at the end of the diurnal light period (ZT12, active phase). Blood concentrations of anthocyanins peaked 1 h after administration in both groups. Maximum blood concentration in rats that consumed bilberry extract daily (852 nM) was higher than that in control rats (630 nM) when the extract was administered at ZT0 but not at ZT12. Daily consumption of anthocyanins increases their absorption rate, but this effect is limited to the beginning of the sleep phase.
每日摄入花青素对生物利用度的影响尚不清楚。本研究评估了在大鼠的活跃期和睡眠期摄入花青素时，每日摄入是否会影响其吸收速率。将 80 只大鼠随机分为两组。第一组大鼠摄入AIN-93G 对照饮食，第二组大鼠摄入含 1%越橘提取物的 AIN-93G 饮食，持续 2 周。禁食 12 小时后，大鼠血浆中未检测到花青素。然后在白天光照期的开始（ZT0，睡眠期）或结束时（ZT12，活跃期），以 500mg/kg 体重的剂量口服给予越橘提取物。两组大鼠在给药后 1 小时血液中花青素浓度达到峰值。当在 ZT0 时给予越橘提取物时，每日摄入越橘提取物的大鼠（852nM）的最大血液浓度高于对照组（630nM），但在 ZT12 时则没有。每日摄入花青素可增加其吸收速率，但这种作用仅限于睡眠期开始时。
