Weaver Connie M, Ferruzzi Mario G, Maiz Maria, Cladis Dennis P, Nakatsu Cindy H, McCabe George P, Lila Mary Ann
School of Exercise and Nutritional Science, San Diego State University, San Diego, CA 92182, USA.
Arkansas Children's Nutrition Center, Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, AR 72202, USA.
Antioxidants (Basel). 2023 May 22;12(5):1136. doi: 10.3390/antiox12051136.
Epidemiological studies have shown associations between polyphenol-rich fruit intake and bone health, and preclinical studies have shown that blueberries improve bone health. To determine the genotype and dose of blueberries that are effective in ameliorating age-related bone loss, a multi-institutional team of investigators performed in vitro, preclinical, and clinical studies on blueberry varieties that differed in flavonoid profiles. Principal component analysis was used to select blueberry genotypes that varied in anthocyanin profiles. Total phenolic content did not predict the bioavailability of polyphenolic compounds in rats. A range in bioavailability was observed in individual polyphenolic compounds across genotypes. Both alpha and beta diversity analyses indicated that gut microbiome profiles varied with blueberry dose in rats. Additionally, the identification of specific taxa, such as Prevotellaceae_UCG-001 and Coriobacteriales, increasing after blueberry consumption adds to the mounting evidence of their role in polyphenol metabolism. All of the sources of variation can inform blueberry breeding practices to influence precision nutrition.
流行病学研究表明，摄入富含多酚的水果与骨骼健康之间存在关联，临床前研究表明蓝莓可改善骨骼健康。为了确定有效改善与年龄相关骨质流失的蓝莓基因型和剂量，一个多机构研究团队对黄酮类化合物谱不同的蓝莓品种进行了体外、临床前和临床研究。主成分分析用于选择花青素谱不同的蓝莓基因型。总酚含量无法预测大鼠体内多酚类化合物的生物利用度。在不同基因型的单个多酚类化合物中观察到生物利用度的范围。α和β多样性分析均表明，大鼠肠道微生物群谱随蓝莓剂量而变化。此外，特定分类群（如普雷沃氏菌科_UCG-001和棒状杆菌目）在食用蓝莓后增加，这进一步证明了它们在多酚代谢中的作用。所有这些变异来源都可为蓝莓育种实践提供参考，以影响精准营养。
