Hesse Martina, Stamm Andreas, Weber Rita, Glünder Gerhard
Clinic for Poultry, University of Veterinary Medicine Hannover, Bünteweg 17, Hannover, Germany.
BMC Res Notes. 2018 Jul 3;11(1):431. doi: 10.1186/s13104-018-3524-1.
Human Salmonellosis continues to be one of the most important foodborne zoonoses worldwide, although a decrease in case numbers has been noted in recent years. It is a foodborne zoonotic infection most commonly associated with the consumption of raw egg products but also with meat consumption including the consumption of poultry products. Turkey flocks in Europe have been reported to be affected by Salmonella infection, too. The present study examines the efficacy of a newly licensed Salmonella life vaccine in reducing infections with the Salmonella serovars Typhimurium and Enteritidis in turkeys. Turkeys were vaccinated the first day of life and at the age of 6 and 16 weeks. Groups of birds which had received different numbers of vaccinations were then submitted to challenge trials with either SE or ST.
In vaccinated birds Salmonella counts in liver and spleen and, less effectively, in caecum were reduced compared to unvaccinated birds. In several groups serum antibody-titers were statistically significantly higher in vaccinated turkeys than in non-vaccinated ones at day seven post infection, but only in one out of six groups at day 14 post infection.
人类沙门氏菌病仍然是全球最重要的食源性人畜共患病之一，尽管近年来病例数有所下降。它是一种食源性人畜共患感染病，最常与食用生蛋制品有关，但也与食用肉类包括禽肉产品有关。据报道，欧洲的火鸡群也受到沙门氏菌感染的影响。本研究考察一种新获批的沙门氏菌活疫苗在减少火鸡感染鼠伤寒沙门氏菌和肠炎沙门氏菌方面的效果。火鸡在出生第一天以及6周龄和16周龄时进行疫苗接种。然后，将接受不同接种次数的火鸡组用肠炎沙门氏菌（SE）或鼠伤寒沙门氏菌（ST）进行攻毒试验。
与未接种疫苗的火鸡相比，接种疫苗的火鸡肝脏、脾脏中的沙门氏菌数量减少，盲肠中的沙门氏菌数量减少效果较差。在感染后第7天，几个组中接种疫苗的火鸡血清抗体滴度在统计学上显著高于未接种疫苗的火鸡，但在感染后第14天，六组中只有一组如此。
