Servicio de Medicina Interna, Universidad de La Laguna, Tenerife, Canary Islands, Spain.
Servicio de Medicina Interna, Universidad de La Laguna, Tenerife, Canary Islands, Spain.
Clin Nutr. 2019 Jun;38(3):1439-1446. doi: 10.1016/j.clnu.2018.06.965. Epub 2018 Jun 23.
In neurodegenerative disorders or in normal aging humans a relationship between muscle mass and/or performance and brain volume was observed, that is not dependent on age or other confounding factors. The aim of the present study is to analyse the relationship between lean mass and handgrip strength in alcoholics, who frequently show brain and muscle atrophy.
It was included 101 male patients aged 58.35 ± 11.59 years, and 44 controls, all of them workers of our hospital, drinkers of less than 20 g ethanol/day, of similar age. Patients and controls underwent dominant handgrip assessment with a Collins' dynamometer, whole body composition analysis by densitometry, and brain computed tomography (CT) examination, with further calculation of several indices indicative of brain atrophy.
among alcoholics, as in other neurodegenerative conditions, there is a relationship between reduced lean mass and brain atrophy, and a close correlation between handgrip strength and brain atrophy, that is independent of age, duration of ethanol consumption and liver function.
在神经退行性疾病或正常衰老的人类中，观察到肌肉质量和/或表现与大脑体积之间存在关系，这种关系不依赖于年龄或其他混杂因素。本研究的目的是分析酒精中毒患者的瘦体重与手握力之间的关系，酒精中毒患者常出现脑和肌肉萎缩。
纳入了 101 名年龄为 58.35±11.59 岁的男性患者和 44 名对照组，所有患者均为我院工作人员，每天饮酒量少于 20g 乙醇，年龄相似。患者和对照组均采用柯林斯测力计进行优势手握力评估，采用密度仪进行全身成分分析，并进行大脑计算机断层扫描（CT）检查，进一步计算几个提示脑萎缩的指标。
1）脑萎缩是酒精中毒患者非常常见的发现，包括肝硬化和非肝硬化患者。2）酒精中毒患者手握力明显下降，瘦体重也明显下降，尤其是手臂和腿部 - 但躯干除外，即使排除腹水患者。3）瘦体重减少与脑萎缩之间存在关系，手握力与脑萎缩之间存在密切相关性，这种相关性独立于年龄和肝功能。4）酒精中毒患者和对照组的总脂肪量没有差异，但脂肪分布存在明显差异：酒精中毒患者手臂脂肪减少，但躯干脂肪增加，因此，如果我们计算外周脂肪/躯干脂肪指数，酒精中毒患者和对照组之间存在明显差异。总脂肪量和脂肪分布均与脑萎缩无关。
在酒精中毒患者中，与其他神经退行性疾病一样，瘦体重减少与脑萎缩之间存在关系，手握力与脑萎缩之间存在密切相关性，这种相关性独立于年龄、乙醇消耗持续时间和肝功能。
