Departamento de Medicina Interna, Universidad de La Laguna, Servicio de Medicina Interna, Hospital Universitario de Canarias, Tenerife, Canary Islands, 38320 La Laguna, Spain.
Departamento de Ciencias Médicas Básicas, Unidad de Fisiología, Universidad de la Laguna, Tenerife, Canary Islands, 38320 La Laguna, Spain.
Int J Mol Sci. 2023 Feb 3;24(3):2981. doi: 10.3390/ijms24032981.
Myostatin acts as a negative regulator of muscle growth. Its effect on fat mass is subject to debate. Among alcoholics, there is a high prevalence of muscle atrophy, and increased fat deposition has been also described in these patients. Myostatin could be involved in these alterations, but its relationships with body composition have been scarcely studied in alcoholic patients. To analyze the behavior of myostatin among alcoholics and its relationship with alcohol intake, liver function, and body composition. We investigated serum myostatin in 59 male patients and 18 controls. Patients were all heavy drinkers admitted with organic complications related to excessive ethanol ingestion. Densitometry analysis was used to assess body composition in 46 patients. Handgrip was assessed in 51 patients. Patients showed lower myostatin values than controls (Z = 3.80; < 0.001). There was a significant relationship between myostatin and fat at the right leg (ρ = 0.32; = 0.028), left leg (ρ = 0.32; = 0.028), trunk (ρ = 0.31, = 0.038), total fat proport ion (ρ = 0.33, = 0.026), and gynecoid fat distribution (ρ = 0.40, = 0.006) but not with lean mass (total lean ρ = 0.07; = 0.63; trunk lean ρ = 0.03; = 0.85; lower limbs ρ = 0.08; = 0.58; upper limbs ρ = 0.04 = 0.82; android ρ = 0.02; = 0.88, or gynoid lean mass ρ = 0.20; = 0.19). In total, 80.43% of patients showed at least one criterion of osteosarcopenic adiposity (OSA). Myostatin was related to OSA obesity. We also observed higher myostatin values among patients with body mass index > 30 kg/m. Serum myostatin was lower among excessive drinkers, and it was related to increased fat deposition among these patients but not to lean mass, handgrip, or bone mineral density.
肌肉生长抑制素作为肌肉生长的负调控因子。其对脂肪量的影响存在争议。在酗酒者中，肌肉萎缩的发病率很高，这些患者的脂肪沉积也增加。肌肉生长抑制素可能与这些改变有关，但在酒精性患者中，其与身体成分的关系尚未得到充分研究。分析酒精性患者中肌肉生长抑制素的行为及其与酒精摄入量、肝功能和身体成分的关系。我们调查了 59 名男性患者和 18 名对照者的血清肌肉生长抑制素。所有患者均为因过量摄入乙醇而导致器官并发症的重度饮酒者。用密度测定法分析 46 例患者的身体成分。用握力计评估 51 例患者的握力。与对照组相比，患者的肌肉生长抑制素值较低（Z = 3.80； < 0.001）。肌肉生长抑制素与右腿（ρ = 0.32； = 0.028）、左腿（ρ = 0.32； = 0.028）、躯干（ρ = 0.31， = 0.038）、总脂肪比例（ρ = 0.33， = 0.026）和女性型脂肪分布（ρ = 0.40， = 0.006）显著相关，但与瘦体重（总瘦体重 ρ = 0.07； = 0.63；躯干瘦体重 ρ = 0.03； = 0.85；下肢 ρ = 0.08； = 0.58；上肢 ρ = 0.04； = 0.82；男性型瘦体重 ρ = 0.02； = 0.88，或女性型瘦体重 ρ = 0.20； = 0.19）无关。总的来说，80.43%的患者至少有一个骨肌减少性肥胖（OSA）标准。肌肉生长抑制素与 OSA 肥胖有关。我们还观察到 BMI > 30 kg/m 的患者的肌肉生长抑制素值更高。血清肌肉生长抑制素在过度饮酒者中较低，与这些患者的脂肪沉积增加有关，但与瘦体重、握力或骨矿物质密度无关。
