Ishikawa Hidehiro, Ii Yuichiro, Niwa Atsushi, Shindo Akihiro, Ito Ai, Matsuura Keita, Sasaki Ryogen, Uno Kenichiro, Maeda Masayuki, Tomimoto Hidekazu
Department of Neurology, Mie University Graduate School of Medicine, Tsu, Mie, Japan.
Department of Neurology, Mie University Graduate School of Medicine, Tsu, Mie, Japan.
J Stroke Cerebrovasc Dis. 2018 Oct;27(10):2623-2626. doi: 10.1016/j.jstrokecerebrovasdis.2018.05.037. Epub 2018 Jul 1.
An 85-year-old woman diagnosed with amyotrophic lateral sclerosis died of pneumonia and was autopsied. Magnetic resonance imaging (MRI) performed 16 days before death revealed an intracortical high-intensity lesion in her right temporal cortex on three-dimensional (3D)-double inversion recovery (DIR) and 3D-fluid-attenuated inversion recovery (FLAIR) images. Histopathological examination indicated a cortical microinfarct (CMI) juxtaposed to cerebral amyloid angiopathy. Recently, in vivo detection of CMIs using 3D-DIR and 3D-FLAIR on 3-tesla MRI has been reported, and postmortem MRI study confirmed the presence of CMIs. This is the first case study to compare CMI findings detected upon premortem MRI to the CMI itself discovered upon postmortem neuropathological examination.
一名85岁被诊断为肌萎缩侧索硬化症的女性死于肺炎并接受了尸检。死亡前16天进行的磁共振成像（MRI）在三维（3D）双反转恢复（DIR）和3D液体衰减反转恢复（FLAIR）图像上显示其右侧颞叶皮质有一个皮质内高强度病变。组织病理学检查表明存在与脑淀粉样血管病相邻的皮质微梗死（CMI）。最近，有报道称在3特斯拉MRI上使用3D-DIR和3D-FLAIR对CMI进行活体检测，尸检后MRI研究证实了CMI的存在。这是首例将生前MRI检测到的CMI结果与死后神经病理学检查发现的CMI本身进行比较的病例研究。
