Er Li-Mian, Li Yong, Er Li, Wu MingLi, Zheng Xiu-Li, Guo Zhan-Jun, Yuan Hu-Fang
Department of Endoscopy, The Fourth Hospital of Hebei Medical University, Shijiazhuang, People's Republic of China.
The Third Department of Surgery, The Fourth Hospital of Hebei Medical University, Shijiazhuang, People's Republic of China.
Ann Clin Lab Sci. 2018 May;48(3):333-337.
Accumulation of single-nucleotide polymorphisms (SNPs) in the displacement loop (D-loop) of mitochondrial DNA (mtDNA) may be associated with cancer risk and disease outcome. We evaluated the predictive value of these SNPs for GEP-NEN outcome. Three SNP sites of nucleotides 16257C/A, 150C/T and 151C/Tdel were identified for statistically significant prediction of postoperative survival in GEP-NEN by univariate analysis with log-rank test. In addition, the minor haplotype of nucleotides 16257A in the hypervariable segment 1(HV1) region of the D-loop was identified for their association with lower survival rate of GEP-NEN (relative risk, 3.390; 95% CI, 1.071~10.729; =0.038) by multivariate analysis with COX hazards model. The analysis of genetic polymorphisms in the mitochondrial D-loop can help identify patient subgroups with a high risk of GEP-NEN outcome.
线粒体DNA（mtDNA）置换环（D环）中单核苷酸多态性（SNP）的积累可能与癌症风险和疾病预后相关。我们评估了这些SNP对GEP-NEN预后的预测价值。通过对数秩检验的单因素分析，确定了核苷酸16257C/A、150C/T和151C/Tdel的三个SNP位点对GEP-NEN术后生存具有统计学意义的预测作用。此外，通过COX风险模型的多因素分析，确定了D环高变区1（HV1）中核苷酸16257A的次要单倍型与GEP-NEN较低的生存率相关（相对风险，3.390；95%可信区间，1.071~10.729；P=0.038）。线粒体D环基因多态性分析有助于识别GEP-NEN预后高风险的患者亚组。
